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Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie-Panstwowy Instytut Badawczy

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Poland Ul. Wawelska 15, 02-034 Warsaw, Poland

  • 150 trials recruiting
  • Non-small cell lung cancer · Breast cancer · Non-small cell lung cancer metastatic
  • Adults and children

About Specializations

Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie-Panstwowy Instytut Badawczy in Warsaw, Poland specialises in clinical trials of conditions such as Non-small cell lung cancer, Breast cancer, Non-small cell lung cancer metastatic, Malignant melanoma, and other specialisations. This site conducts important research.

Main research areas of the site

Advanced Liver Cancer Research

The Narodowy Instytut Onkologii Im. Marii Sklodowskiej‑Curie‑Panstwowy Instytut Badawczy in Warsaw is conducting a series of trials focused on Hepatocellular Carcinoma, exploring new combination therapy approaches to improve response rates and survival outcomes.

  • Evaluate efficacy of anti‑PD‑1 based combinations
  • Assess safety of dual checkpoint blockade
  • Compare progression‑free survival across regimens
  • Investigate biomarkers predicting treatment benefit
  • Explore first‑line therapeutic options for advanced disease

Across 11 trials, 55 investigators are collaborating to bring innovative liver cancer therapies to patients in Europe.

Metastatic Colorectal Cancer Studies

Research at the institute includes targeted investigations of Microsatellite Instability‑High and KRAS mutant metastatic colorectal cancer, testing novel agents and personalized treatment strategies.

  • Identify optimal dosing of targeted agents
  • Test efficacy of checkpoint inhibitors in MSI‑H disease
  • Determine safety of multi‑arm regimens
  • Analyze response rates in KRAS‑mutant tumors
  • Validate predictive biomarkers for therapy selection

The program emphasizes personalized medicine and collaborates with leading European oncology networks.

Immuno‑oncology Combination Trials

The site is advancing immune checkpoint inhibitor research by evaluating combinations such as relatlimab with nivolumab and triple‑agent regimens that include atezolizumab, bevacizumab, and tiragolumab.

  • Compare monotherapy versus combination response
  • Measure overall survival benefit of added agents
  • Assess tolerability of triple‑agent protocols
  • Explore synergy between anti‑PD‑L1 and anti‑CTLA‑4 antibodies
  • Monitor immune‑related adverse events across cohorts

These efforts reflect a commitment to expanding immunotherapy options for patients across Europe.

Solid Tumor & Biomarker Research

A broad solid tumor program investigates KRAS mutation driven cancers and other biomarker‑defined subsets, integrating genomic profiling to guide early‑phase studies such as the MK‑1084 trial.

  • Investigate novel agents in KRAS‑mutant cancers
  • Evaluate response in lung cancer cohorts
  • Determine biomarker prevalence across tumor types
  • Conduct early‑phase safety assessments of emerging drugs
  • Integrate genomic data into trial design for precision therapy

As Poland’s national oncology institute, the center supports a multidisciplinary team of 55 investigators dedicated to cutting‑edge cancer research.

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Site location
Ul. Wawelska 1502-034 WarsawPoland
Recruiting now
150 trials
Conditions studied
203
Partner status
Verified site

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Ongoing trials

Clinical trials currently enrolling participants at this site.

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Recruitment status
Quick filters

457 clinical trials

Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Golimumab
  • Sponsor:Janssen Cilag International

A study of loxo-435, enfortumab vedotin, and pembrolizumab in adults with advanced or metastatic bladder cancer

Registered drug
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Enfortumab Vedotin
  • Sponsor:Eli Lilly & Co.

Study of sotorasib, panitumumab and a drug combination for patients with metastatic colorectal cancer with KRAS p.G12C mutation.

Registered drugNo placebo
Countries:PolandPoland
  • Participants:18–64 years
  • Substances:Bevacizumab
  • Sponsor:Amgen Inc.

Breast cancer

Recruiting

Study of BNT327 and a drug combination for patients with untreated metastatic or locally recurrent triple-negative breast cancer

Registered drug
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:BioNTech SE

Study of BNT327 with etoposide and carboplatin compared to atezolizumab with etoposide and carboplatin for patients with untreated extensive-stage small-cell lung cancer

Registered drugNo placebo
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Atezolizumab
  • Sponsor:BioNTech SE

A study comparing XL092 versus everolimus in patients with previously treated advanced or metastatic neuroendocrine tumors

Registered drugNo placebo
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Everolimus
  • Sponsor:Exelixis Inc.

A Study of Ivonescimab Combined with Fluorouracil, Folinic Acid, and Oxaliplatin Compared to Bevacizumab for Patients with Metastatic Colorectal Cancer

Registered drugNo placebo
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Bevacizumab
  • Sponsor:Summit Therapeutics Inc.

Study of GSK5764227 alone and in combination for patients with previously treated advanced gastrointestinal tumors that cannot be removed by surgery or have spread

InvestigationalNo placebo
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:GSK5764227
  • Sponsor:Glaxosmithkline Research & Development Limited

Crohn's disease

Recruiting

Study of tulisokibart compared to placebo in adults with moderate to severe Crohn's disease

Investigational
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Tulisokibart
  • Sponsor:Merck Sharp & Dohme LLC

Study on the Safety and Effectiveness of BNT327 with Chemotherapy for Patients with Non-Small Cell Lung Cancer

Registered drugNo placebo
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:BNT327
  • Sponsor:BioNTech SE

Study on Long-term Safety of Nivolumab and Drug Combination for Cancer Patients from Previous BMS Trials

Registered drugNo placebo
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Bevacizumab
  • Sponsor:Bristol-Myers Squibb Services Unlimited Company

Study of Tucatinib, Trastuzumab, and mFOLFOX6 for Patients with HER2+ Metastatic Colorectal Cancer

Registered drugNo placebo
Countries:PolandPoland
  • Participants:18–64 years · 65+ years
  • Substances:Bevacizumab
  • Sponsor:Seagen Inc.
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