Multispecialty hospital for active treatment Sveta Sofia EOOD

The department investigates cardiovascular disease through trials that evaluate novel agents for heart attack prevention, blood pressure control, and heart failure management.

• Acute myocardial infarction
• Heart failure with preserved or mildly reduced ejection fraction
• Hypertension and high cardiovascular risk
• Hypercholesterolemia and triglyceride disorders
• Venous thromboembolism

The goal is to introduce safer, more effective therapies that lower cardiovascular events and improve quality of life.

Research in digestive system diseases targets inflammatory bowel conditions and related gastrointestinal disorders, testing treatments that induce remission and heal the intestinal lining.

• Ulcerative colitis
• Inflammatory bowel disease (moderate to severe)
• Cancer cachexia
• Colitis ulcerative

Studies aim to reduce flare‑ups, improve nutrient absorption, and support patients with chronic gut inflammation.

The site conducts trials on eye diseases to explore therapies that slow vision loss and restore retinal health.

• Geographic atrophy secondary to age‑related macular degeneration

Efforts focus on delivering treatments that preserve visual acuity and enhance daily functioning.

Investigations into hemic and lymphatic diseases include clotting disorders and platelet deficiencies, with a focus on safer prophylaxis and recovery.

• Severe hemophilia A and B
• Cancer‑associated thrombosis
• Chemotherapy‑induced thrombocytopenia

The aim is to prevent bleeding complications and reduce clot‑related risks in vulnerable patients.

Trials addressing immune system diseases evaluate innovative immunomodulators for autoimmune conditions, seeking durable remission and symptom relief.

• Sjögren’s syndrome
• Systemic lupus erythematosus
• Rheumatoid arthritis
• Relapsing multiple sclerosis
• Alopecia areata

These studies strive to modulate immune activity without compromising overall health.

The department explores treatments for musculoskeletal diseases, focusing on agents that reduce inflammation and preserve joint function.

• Rheumatoid arthritis
• Chronic joint pain associated with autoimmune disorders

Objectives include improving mobility and decreasing reliance on long‑term steroids.

Oncology research at the hospital targets neoplasms, testing targeted therapies and immunotherapies across a spectrum of solid tumors.

• Advanced non‑small cell lung cancer with HER2 or EGFR mutations
• Melanoma (adjuvant setting)
• Head and neck squamous cell carcinoma
• Advanced solid malignancies
• Solid tumors undergoing chemotherapy

The purpose is to extend survival, delay progression, and improve post‑surgical outcomes.

Studies on nervous system diseases focus on demyelinating disorders, evaluating compounds that may lower relapse rates and protect neural tissue.

• Relapsing multiple sclerosis

Researchers aim to achieve longer remission periods and preserve neurological function.

Research in nutritional and metabolic diseases assesses lipid‑lowering agents and weight‑modulating therapies to address dyslipidemia and obesity.

• Hypertriglyceridemia and severe hypertriglyceridemia
• Hypercholesterolemia
• Obesity associated with heart failure

The goal is to reduce cardiovascular risk factors and support metabolic health.

Clinical work on respiratory tract diseases evaluates inhaled and systemic treatments that improve lung function and reduce exacerbations.

• Chronic obstructive pulmonary disease (COPD)
• Mild asthma
• Non‑cystic fibrosis bronchiectasis with pathogenic bacteria

Trials seek to enhance breathing capacity, lower infection rates, and improve daily activity tolerance.

The department’s focus on skin and connective tissue diseases includes biologics aimed at reducing inflammation and skin lesions.

• Atopic dermatitis
• Plaque psoriasis
• Alopecia areata

Objectives are to achieve clearer skin, lessen itching, and improve patients’ self‑esteem.

Investigations into virus diseases target chronic viral infections, testing antiviral compounds for safety and viral suppression.

• Chronic hepatitis B virus infection

The aim is to achieve sustained viral load reduction and prevent liver disease progression.

Additional studies at the site encompass a range of conditions that do not fit neatly into other categories, exploring innovative approaches across multiple systems.

• Cancer‑associated thrombosis in solid tumor patients
• Geographic atrophy related to age‑related macular degeneration
• Body‑weight loss in pancreatic cancer patients

These projects aim to fill therapeutic gaps and introduce novel treatment concepts.