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Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD

Research site

Bulgaria Ulitsa Otets Paisiy 72, 5100 Gorna Oryahovitsa, Bulgaria

  • 15 trials recruiting
  • Colitis ulcerative · Crohn's disease · Asthma
  • Adults and children

About Specializations

Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD in Gorna Oryahovitsa, Bulgaria specialises in clinical trials of conditions such as Colitis ulcerative, Crohn's disease, Asthma, Erosive oesophagitis, and other specialisations. This site conducts important research.

Main research areas of the site

Bacterial Infections and Mycoses

The department is investigating bacterial gut infections, aiming to reduce recurrence and improve patient outcomes through innovative antimicrobial and microbiome‑based approaches.

  • Clostridioides difficile infection recurrence prevention strategies
  • Evaluation of novel oral antibiotics
  • Microbiome restoration therapies in post‑infection patients

Research is carried out at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, which currently hosts 29 clinical trials led by 14 investigators.

Cardiovascular Diseases

Studies focus on acute cerebrovascular events, testing thrombolytic agents to extend therapeutic windows and improve functional recovery after stroke.

  • Acute Ischemic Stroke treatment optimization
  • Extended‑window thrombolysis efficacy
  • Long‑term functional outcome assessment

The site’s cardiovascular program is part of the broader effort at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD.

Digestive System Diseases

A robust pipeline of trials addresses inflammatory bowel conditions and gastro‑esophageal disorders, seeking to induce remission and heal mucosal damage.

  • Crohn's disease induction and maintenance therapies
  • Ulcerative colitis endoscopic response evaluation
  • Erosive esophagitis healing with novel acid suppression agents

Ongoing work is conducted at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, supporting 29 trials across specialties.

Immune System Diseases

The unit explores immune‑modulating treatments for chronic inflammatory disorders, combining biologics with metabolic agents to enhance efficacy.

  • Biologic combination strategies in inflammatory bowel disease
  • Safety profiling of new immune‑targeted antibodies
  • Immune pathway modulation in asthma and related conditions

These investigations are part of the research portfolio of Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD.

Nutritional and Metabolic Diseases

Trials target liver metabolic dysfunction, obesity, and kidney health, evaluating agents that reduce fibrosis, promote weight loss, and slow renal decline.

  • Metabolic Dysfunction‑Associated Steatohepatitis fibrosis regression studies
  • Combination of weight‑loss therapy with IBD treatment
  • Non‑diabetic chronic kidney disease progression delay

The metabolic research program operates at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, contributing to the site’s 29 active trials.

Respiratory Tract Diseases

Focused on asthma management, the department evaluates novel biologics and inhaled therapies to improve lung function and biomarkers of inflammation.

  • Asthma control with anti‑TSLP antibody
  • Exhaled nitric oxide as a pharmacodynamic marker
  • Comparative effectiveness of new inhaled bronchodilators

Research is carried out at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, integrating respiratory studies within its broader clinical trial portfolio.

Virus Diseases

The site conducts antiviral research, particularly in pediatric COVID‑19, to define safe dosing and assess therapeutic benefit in non‑hospitalized patients.

  • SARS‑CoV‑2 Infection pediatric pharmacokinetic modeling
  • Safety and tolerability of oral antiviral regimens in children
  • Dosing optimization to match adult exposure levels

These virus‑focused investigations are part of the work at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, which currently oversees 29 trials.

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Site location
Ulitsa Otets Paisiy 725100 Gorna OryahovitsaBulgaria
Recruiting now
15 trials
Conditions studied
15

More sites in Gorna OryahovitsaBulgaria

Recruiting now

Ongoing trials

Clinical trials currently enrolling participants at this site.

Condition
Type of trial
Recruitment status
Quick filters

30 clinical trials

Long‑Term Safety and Efficacy of SPY001-001, SPY002 and SPY003 in Adults with Ulcerative Colitis

Investigational
Countries:BulgariaBulgaria
  • Participants:18–64 years · 65+ years
  • Substances:SPY002
  • Sponsor:Spyre Therapeutics Inc.

A Phase 3 Study of Efimosfermin Alfa to Assess Safety and Tolerability in Adults with F2‑F3 Stage Metabolic Dysfunction‑Associated Steatohepatitis (MASH)

Investigational
Countries:BulgariaBulgaria
  • Participants:18–64 years · 65+ years
  • Sponsor:Glaxosmithkline Research & Development Limited

Safety and Efficacy of Efimosfermin Alfa in Participants with Biopsy‑Confirmed F2‑ or F3‑Stage Metabolic Dysfunction‑Associated Steatohepatitis (MASH)

Investigational
Countries:BulgariaBulgaria
  • Participants:18–64 years · 65+ years
  • Sponsor:Glaxosmithkline Research & Development Limited

Crohn's disease

Recruiting

A study to evaluate the effectiveness and safety of duvakitug in patients with moderate to severe Crohn's disease

Investigational
Countries:BulgariaBulgaria
  • Participants:0–17 years · 18–64 years · 65+ years
  • Substances:Duvakitug
  • Sponsor:Sanofi-Aventis Recherche & Developpement

Crohn's disease

Recruiting

A study to evaluate the efficacy and safety of duvakitug in patients with moderate to severe Crohn's disease

Investigational
Countries:BulgariaBulgaria
  • Participants:0–17 years · 18–64 years · 65+ years
  • Substances:Duvakitug
  • Sponsor:Sanofi-Aventis Recherche & Developpement

A Study of Long-acting Antibodies SPY001-001 and SPY002 Alone and Combined for Adults with Moderate to Severe Ulcerative Colitis

Investigational
Countries:BulgariaBulgaria
  • Participants:18–64 years · 65+ years
  • Substances:SPY002
  • Sponsor:Spyre Therapeutics Inc.

A study of duvakitug for patients with moderately to severely active ulcerative colitis to see if it works and is safe as maintenance therapy

Investigational
Countries:BulgariaBulgaria
  • Participants:0–17 years · 18–64 years · 65+ years
  • Substances:Duvakitug
  • Sponsor:Sanofi-Aventis Recherche & Developpement

A study testing duvakitug for patients with moderately to severely active ulcerative colitis

Investigational
Countries:BulgariaBulgaria
  • Participants:0–17 years · 18–64 years · 65+ years
  • Substances:Duvakitug
  • Sponsor:Sanofi-Aventis Recherche & Developpement

Crohn's disease

Recruiting

Study of RO7790121 (afimkibart) for Treatment and Long-term Management in Adults with Moderate to Severe Crohn's Disease

Investigational
Countries:BulgariaBulgaria
  • Participants:18–64 years · 65+ years
  • Substances:RO7790121
  • Sponsor:F. Hoffmann-La Roche AG

Study on the Effects of Pegozafermin for Patients with Nonalcoholic Steatohepatitis (NASH) and Fibrosis

Investigational
Countries:BulgariaBulgaria
  • Participants:18–64 years · 65+ years
  • Substances:BIO89-100
  • Sponsor:F. Hoffmann-La Roche AG

Study of Pegozafermin Treatment for Patients with Liver Cirrhosis due to Metabolic Dysfunction-Associated Steatohepatitis (MASH)

Investigational
Countries:BulgariaBulgaria
  • Participants:18–64 years · 65+ years
  • Substances:BIO89-100
  • Sponsor:F. Hoffmann-La Roche AG

A study to evaluate the effectiveness of tenecteplase in patients with acute ischemic stroke who are more than 4.5 hours after their last known well time.

Registered drugNo placebo
Countries:BulgariaBulgaria
  • Participants:18–64 years · 65+ years
  • Substances:Tenecteplase
  • Sponsor:Boehringer Ingelheim International GmbH
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