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MUDr. Libor Nechvatal s.r.o.

Research site

Czechia Hybesova 289/43, Stare Brno, 602 00 Brno, Czechia

  • 5 trials recruiting
  • Arteriosclerosis · Cardiac failure · Heart failure with reduced ejection fraction
  • Adult patients

About Specializations

MUDr. Libor Nechvatal s.r.o. in Brno, Czechia specialises in clinical trials of conditions such as Arteriosclerosis, Cardiac failure, Heart failure with reduced ejection fraction, Cardiac failure chronic, and other specialisations. This site conducts important research.

Main research areas of the site

Heart Failure and Kidney Function

The medical center is at the forefront of research in heart failure and its intersection with kidney function. The ongoing studies aim to explore innovative treatments that address the complex interplay between these two critical systems.

  • Balcinrenone/Dapagliflozin Combination Therapy
  • Cardiovascular Death and Heart Failure Events
  • Hospitalization Reduction Strategies

By focusing on the dual impact of heart and kidney health, the center is pioneering approaches that could significantly improve patient outcomes and reduce the burden of hospitalizations.

Atherosclerotic Cardiovascular Disease (ASCVD)

Specializing in atherosclerotic cardiovascular disease, the center is dedicated to advancing therapeutic strategies that mitigate the risks associated with this prevalent condition. The research is centered on innovative pharmacological interventions.

  • Inclisiran Efficacy in Reducing Cardiovascular Events
  • Prevention of Heart Attacks and Strokes
  • LDL-C Management in ASCVD Patients

Through cutting-edge research, the center is contributing to the development of treatments that aim to lower the incidence of major cardiovascular events, thereby enhancing the quality of life for patients with vascular disease.

Heart Failure Management

Focusing on heart failure, the center is engaged in research that seeks to refine treatment protocols and improve patient outcomes. The studies are designed to assess the efficacy of novel therapeutic agents.

  • XXB750 Dose-Response Analysis
  • NT-proBNP Reduction Strategies
  • Standard of Care Optimization

By investigating new treatment modalities, the center is at the forefront of efforts to enhance the management of heart failure, offering hope for improved therapeutic options.

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Site location
Hybesova 289/43, Stare Brno602 00 BrnoCzechia
Recruiting now
5 trials
Conditions studied
7

More sites in BrnoCzechia

Recruiting now

Ongoing trials

Clinical trials currently enrolling participants at this site.

Condition
Type of trial
Recruitment status
Quick filters

16 clinical trials

Cardiac failure

Recruiting

Study of maridebart cafraglutide for patients with heart failure with preserved or mildly reduced ejection fraction and obesity

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Maridebart Cafraglutide
  • Sponsor:Amgen Inc.

Cardiac failure

Recruiting

Study on BI 690517 and Empagliflozin for Patients with Heart Failure and Preserved Ejection Fraction

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:BI 690517
  • Sponsor:Boehringer Ingelheim International GmbH

Effect of elecoglipron plus dapagliflozin on cardiovascular outcomes in adults with heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF)

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:AZD5004
  • Sponsor:AstraZeneca AB

Cardiac failure+1

Recruiting

Study of Zenagamtide (NNC0487-0111) versus placebo in patients with heart failure with preserved or mildly reduced ejection fraction and obesity

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:POLYPEPTIDE CONSISTING OF A GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST AND AN AMYLIN RECEPTOR AGONIST, CONNECTED BY A LINKER WITH 4 GLYCINE RESIDUES, AND CONNECTED TO A C18 FATTY ACID SIDE CHAIN
  • Sponsor:Novo Nordisk A/S

Study on Ferric Derisomaltose for Patients with Iron Deficiency and Chronic Heart Failure

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Ferric Derisomaltose
  • Sponsor:Pharmacosmos A/S

Arteriosclerosis

Not yet recruiting

Study of olpasiran to prevent first major cardiovascular events in people with high levels of lipoprotein(a)

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Sponsor:Amgen Inc.

Arteriosclerosis

Not recruiting

A study to evaluate the effect of olpasiran on major cardiovascular events in patients with atherosclerotic cardiovascular disease and high levels of lipoprotein(a)

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Sponsor:Amgen Inc.

Cardiac failure

Not recruiting

A study comparing ziltivekimab to placebo in patients with heart failure with mildly reduced or preserved ejection fraction and inflammation

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Ziltivekimab
  • Sponsor:Novo Nordisk A/S

Arteriosclerosis

Not recruiting

Study of maridebart cafraglutide to reduce cardiovascular problems in overweight or obese patients with atherosclerotic cardiovascular disease

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Maridebart Cafraglutide
  • Sponsor:Amgen Inc.

Arteriosclerosis

Not recruiting

Study of inclisiran to prevent heart attacks and strokes in people with atherosclerotic cardiovascular disease

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Atorvastatin
  • Sponsor:Novartis Pharma AG

Arteriosclerosis

Not recruiting

Study on Inclisiran for Preventing Heart Disease in High-Risk Patients

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Inclisiran
  • Sponsor:Novartis Pharma AG

Arteriosclerosis

Not recruiting

Long-term safety study of pelacarsen in patients with atherosclerotic cardiovascular disease who completed the Lp(a)HORIZON trial

InvestigationalNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Pelacarsen
  • Sponsor:Novartis Pharma AG
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