Medisch Spectrum Twente

The Reumatologie department at Medisch Spectrum Twente advances care for patients with immune system diseases and related musculoskeletal conditions, testing innovative biologic agents and refining treatment strategies to improve quality of life.

• Rheumatoid arthritis
• Psoriatic arthritis
• Axial spondyloarthritis
• Sjögren's Disease
• Skin and connective tissue disorders

Ongoing trials evaluate safety, efficacy, and cost‑effectiveness of new DMARDs and targeted therapies, positioning the site as a hub for rheumatology innovation.

Research at the hospital spans a broad range of neoplasms and hematologic malignancies, focusing on novel drug combinations, immunotherapies, and personalized approaches to extend survival and enhance tolerability.

• Acute Myeloid Leukemia
• Chronic Lymphocytic Leukemia
• Multiple Myeloma
• Breast Cancer (including triple‑negative)
• Colorectal Cancer and liver metastases
• Melanoma (cutaneous and metastatic)
• Ovarian Cancer (including platinum‑resistant)
• Pancreatic Cancer (resectable and metastatic)

The site’s oncology program integrates cutting‑edge immuno‑oncology trials and evaluates maintenance strategies to improve long‑term outcomes.

The centre conducts extensive work on cardiovascular diseases and metabolic disorders, investigating therapies that reduce events such as myocardial infarction, heart failure, and peripheral arterial disease while addressing obesity‑related risk.

• Acute myocardial infarction (STEMI/NSTEMI)
• Chronic heart failure with preserved ejection fraction
• Atrial fibrillation
• Peripheral arterial disease
• Atherosclerotic cardiovascular disease
• Obesity and metabolic syndrome

Trials test lipid‑lowering antibodies, anti‑inflammatory agents, and novel dosing regimens to lower major adverse cardiovascular events.

Focused investigations target respiratory tract diseases and serious infections, aiming to improve acute care and chronic management through new therapeutics and diagnostic tools.

• Acute Respiratory Distress Syndrome (ARDS)
• Chronic Obstructive Pulmonary Disease
• Severe eosinophilic asthma
• Respiratory syncytial virus infection
• Sepsis and community‑acquired pneumonia

Studies evaluate anti‑inflammatory peptides, monoclonal antibodies, and adaptive platform designs to accelerate effective treatment discovery.

The department addresses digestive system diseases ranging from inflammatory bowel conditions to complex oncologic surgeries, seeking to refine peri‑operative care and novel systemic therapies.

• Inflammatory bowel disease
• Chronic pancreatitis
• Pancreatic head carcinoma (resectable and borderline)
• Colorectal cancer with liver metastases
• Hepatic arterial infusion chemotherapy

Trials compare neoadjuvant regimens, assess pain‑relief strategies, and explore biomarker‑guided approaches to improve surgical outcomes.

Leveraging advanced analytical, diagnostic and therapeutic techniques, the site integrates imaging, biomarker profiling, and surgical innovations to support precision medicine across specialties.

• Integrated omics for treatment response prediction
• High‑resolution imaging for tumor resection margins
• Novel surgical devices and operative protocols
• Real‑time monitoring of inflammatory markers
• Platform trials evaluating multiple interventions simultaneously

These technology‑focused studies enhance trial efficiency and patient safety, reinforcing Medisch Spectrum Twente’s role as a leader in clinical innovation.