Medical Center Haaglanden

At Medical Center Haaglanden, researchers are investigating atherosclerotic cardiovascular disease and the role of elevated lipoprotein(a) in heart health. The trials aim to test new lipid‑lowering therapies and determine whether they can reduce major adverse cardiovascular events such as heart attacks and strokes.

• Evaluation of obicetrapib for ASCVD patients
• Olpasiran’s effect on Lp(a) reduction
• Impact on cardiovascular event rates
• Safety of novel lipid‑modifying agents
• Long‑term outcomes in high‑risk populations

With 38 investigators leading 7 active studies, the site combines cardiology expertise and advanced imaging to improve prevention strategies for patients across the Netherlands.

The centre’s reproductive health program focuses on women experiencing unexplained subfertility and recurrent pregnancy loss. Clinical trials are testing whether adding progesterone support or low‑dose prednisolone can increase the chance of a live birth in couples undergoing assisted conception.

• Progesterone luteal phase support in IUI cycles
• Cost‑effectiveness of mild ovarian stimulation protocols
• Prednisolone treatment for recurrent miscarriage
• Live‑birth rate as primary outcome
• Hormonal optimization for early pregnancy

The multidisciplinary team of obstetricians, endocrinologists and fertility specialists collaborates to translate these findings into everyday clinical practice.

Oncology research at the hospital targets aggressive cancers such as Diffuse Large B‑Cell Lymphoma and metastatic castration‑resistant prostate cancer. Trials evaluate the addition of immunotherapies to standard chemotherapy to improve survival and delay disease progression.

• Epcoritamab combined with R‑CHOP in newly diagnosed DLBCL
• Pembrolizumab plus enzalutamide versus enzalutamide alone
• Progression‑free survival as primary endpoint
• Overall survival and radiographic response assessment
• Biomarker‑driven patient selection

The oncology department works closely with academic partners to bring cutting‑edge immuno‑oncology treatments to patients in the region.

This research stream explores the underlying physiological mechanisms of fertility and urinary health, aiming to improve diagnostic tools and therapeutic options for conditions such as unexplained infertility and hormonal imbalance.

• Hormonal stimulation protocols for IUI
• Biomarker analysis of luteal phase adequacy
• Evaluation of uterine environment in early pregnancy
• Integration of urinary biomarkers in reproductive assessment
• Translational studies linking physiology to clinical outcomes

By linking basic science with patient‑centered trials, the department seeks to enhance fertility care and reduce miscarriage rates for women served by the Medical Center Haaglanden.