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Klinikum Worms gGmbH

Research site

Germany Gabriel-Von-Seidl-Strasse 81, Herrnsheim, 67550 Worms, Germany

  • 18 trials recruiting
  • Breast cancer · Breast cancer metastatic · Hormone receptor positive HER2 negative breast cancer
  • Adults and children

About Specializations

Klinikum Worms gGmbH in Worms, Germany specialises in clinical trials of conditions such as Breast cancer, Breast cancer metastatic, Hormone receptor positive HER2 negative breast cancer, Atrial fibrillation, and other specialisations. This site conducts important research.

Main research areas of the site

Cardiovascular Diseases

The cardiovascular research at Klinikum Worms gGmbH addresses patients with acute coronary syndrome and atrial fibrillation, aiming to test new oral anticoagulants for reducing heart attacks, strokes, and related complications.

  • Evaluation of novel anticoagulant agents compared with standard therapy
  • Assessment of major adverse cardiac events (MACE) reduction
  • Safety profiling of bleeding risk versus established drugs
  • Prevention of stroke and systemic embolism in high‑risk atrial fibrillation
  • Comparative effectiveness of milvexian and asundexian

The site’s team of seven investigators collaborates closely to generate robust data that could shape future treatment guidelines.

Breast Cancer Research

In the neoplasms portfolio, Klinikum Worms gGmbH focuses on ER+/HER2- early breast cancer and HER2/neu positive breast cancer, exploring innovative therapies to lower recurrence after surgery and standard adjuvant treatment.

  • Immunotherapeutic peptide vaccine GLSI-100 in HER2‑positive disease
  • Oral selective estrogen degrader camizestrant with or without abemaciclib
  • Strategies to improve disease‑free survival in high‑risk patients
  • Integration of novel agents into endocrine therapy regimens
  • Evaluation of residual disease response after neoadjuvant therapy

These studies are conducted by a multidisciplinary team aiming to provide new options for women battling breast cancer.

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Site location
Gabriel-Von-Seidl-Strasse 81, Herrnsheim67550 WormsGermany
Recruiting now
18 trials
Conditions studied
31

More sites in WormsGermany

Recruiting now

Ongoing trials

Clinical trials currently enrolling participants at this site.

Condition
Type of trial
Recruitment status
Quick filters

29 clinical trials

Breast cancer

Recruiting

Study of BNT327 and a drug combination for patients with untreated metastatic or locally recurrent triple-negative breast cancer

Registered drug
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:BioNTech SE

Study of vicadrostat and empagliflozin combination in patients with type 2 diabetes, high blood pressure and cardiovascular disease

Registered drug
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:BI 690517
  • Sponsor:Boehringer Ingelheim Espana S.A.

Breast cancer

Recruiting

Study on the Safety and Effectiveness of Trastuzumab Deruxtecan vs. Palbociclib-Based Drug Combination for Advanced HR-Positive, HER2-Low Breast Cancer Patients

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Abemaciclib
  • Sponsor:Medica Scientia Innovation Research S.L.

Breast cancer+1

Recruiting

Study on the Effectiveness of GP2 and Sargramostim for HER2 Positive Breast Cancer Patients with Residual Disease or High-Risk After Standard Therapy

Investigational
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Sargramostim
  • Sponsor:Greenwich LifeSciences Inc.

Breast cancer+4

Recruiting

Study of elacestrant and ribociclib compared to standard treatment for patients with high-risk ER+/HER2- early breast cancer

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Elacestrant
  • Sponsor:WSG Women's Cancer Study Group GmbH

A study of palazestrant and ribociclib compared to letrozole and ribociclib for patients with advanced ER+ HER2- breast cancer

Registered drug
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Letrozole
  • Sponsor:Olema Pharmaceuticals Inc.

Phase 1b-2 Study of Elacestrant and Abemaciclib in Patients with Brain Metastases from ER-Positive, HER2-Negative Breast Cancer

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Abemaciclib
  • Sponsor:Stemline Therapeutics Inc.

Breast cancer+3

Recruiting

A study testing zanidatamab combined with chemotherapy before surgery in patients with HER2-positive breast cancer

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:Jazz Pharmaceuticals Ireland Limited

Study of ribociclib with or without chemotherapy for patients with hormone receptor positive, HER2 negative early breast cancer at intermediate risk

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Anastrozole
  • Sponsor:Unicancer

Cardiac failure

Recruiting

Evaluating the Effect of Vicadrostat and Empagliflozin Combination Compared to Empagliflozin Alone in Patients with Heart Failure and Reduced Left Ventricular Function

Registered drug
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:BI 690517
  • Sponsor:Boehringer Ingelheim International GmbH

Comparison of niraparib alone versus niraparib with bevacizumab in patients with newly diagnosed advanced ovarian cancer after chemotherapy with carboplatin and paclitaxel

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Bevacizumab
  • Sponsor:AGO Research GmbH

Study on Elacestrant and Everolimus for Patients with Advanced ER+/HER2- Breast Cancer Resistant to Endocrine Therapy and CDK4/6 Inhibitors

Registered drug
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Elacestrant
  • Sponsor:Medica Scientia Innovation Research S.L.
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