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Kliniken der Stadt Koeln gGmbH

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Germany Ostmerheimer Strasse 200, Merheim, 51109 Cologne, Germany

  • 34 trials recruiting
  • Non-small cell lung cancer · Breast cancer · Breast cancer female
  • Adults and children

About Specializations

Main research areas of the site

Respiratory Tract Diseases

The department is evaluating new oral agents for Idiopathic Pulmonary Fibrosis, with the goal of slowing disease progression and preserving lung capacity.

  • Oral MBS2320 assessment in IPF
  • Impact on forced vital capacity
  • Safety profile compared with placebo

Research is conducted at Kliniken der Stadt Koeln gGmbH in Cologne, Germany, involving 26 investigators and a total of five active trials.

Eye Diseases

A focused study on Neurotrophic Keratopathy examines a novel ophthalmic solution designed to promote corneal healing and maintain visual function.

  • RGN-259 ophthalmic solution safety and efficacy
  • Double‑blind placebo‑controlled design
  • Central review of corneal outcomes

The trial takes place within the Department of Anesthesiology and Critical Care Medicine at Merheim Medical Center, supporting multidisciplinary patient care.

Neoplasms

Ongoing investigations target Resectable Stage II‑IIIB Non‑small cell lung cancer and Unresectable Pleural Mesothelioma, testing innovative immunotherapy‑chemo combinations to improve overall survival.

  • Volrustomig with carboplatin/pemetrexed versus standard of care
  • Pre‑ and postoperative nivolumab integration
  • Event‑free survival assessment by blinded review

These oncology trials are coordinated at the Merheim campus, leveraging the expertise of 26 investigators across the institution.

Disorders of Environmental Origin

A critical‑care trial evaluates high‑dose intravenous vitamin C for severe burn patients, aiming to reduce persistent organ dysfunction and mortality when added to standard therapy.

  • High‑dose vitamin C infusion protocol
  • 28‑day composite outcome of organ dysfunction and mortality
  • Placebo‑controlled randomized design

Conducted at the Merheim Medical Center, the study benefits from the department’s extensive experience in managing complex trauma cases.

Bacterial Infections and Mycoses

While current trials emphasize oncology and respiratory disease, the department retains strong capabilities in treating infection‑related complications in critical care, laying groundwork for future antimicrobial studies.

  • Critical‑care infection monitoring
  • Integration of antimicrobial guidelines
  • Readiness for future bacterial/mycotic trial enrollment

The facility’s comprehensive infection management program supports patient safety and positions the site for upcoming research initiatives.

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Site location
Ostmerheimer Strasse 200, Merheim51109 CologneGermany
Recruiting now
34 trials
Conditions studied
65
Partner status
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Ongoing trials

Clinical trials currently enrolling participants at this site.

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84 clinical trials

Phase 3 study of ZL-1310 versus topotecan hydrochloride in patients with relapsed small cell lung cancer

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Topotecan Hydrochloride
  • Sponsor:Zai Lab (US) LLC

Phase III Randomized Study of Rilvegostomig vs. Pembrolizumab with Platinum-based Chemotherapy in PD-L1 Expressing Metastatic Squamous NSCLC

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:AstraZeneca AB

Study on Tozorakimab for Patients Hospitalized with Severe Viral Lung Infections Needing Oxygen

Investigational
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Tozorakimab
  • Sponsor:AstraZeneca AB

Study comparing rilvegostomig plus chemotherapy versus pembrolizumab plus chemotherapy for first-line treatment in patients with metastatic non-squamous lung cancer with PD-L1 expression

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:AstraZeneca AB

Phase 2 Study of Imzokitug with drug combination as First‑Line Treatment for Adults with Locally Advanced or Metastatic Non‑Small Cell Lung Cancer (NSCLC)

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:BMS-986340
  • Sponsor:Bristol-Myers Squibb Services Unlimited Company

Study of BGB-43395 with letrozole versus CDK4/6 inhibitor drug combination with letrozole in patients with untreated advanced HR‑positive HER2‑negative breast cancer

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Abemaciclib
  • Sponsor:BeOne Medicines I GmbH

A Study of ABBV-706 to Assess Safety and Efficacy Compared with Standard Drug Combination in Adults with Relapsed or Refractory Small Cell Lung Cancer

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Topotecan
  • Sponsor:AbbVie Deutschland GmbH & Co. KG

Pumitamig Versus Pembrolizumab in Patients With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Pembrolizumab
  • Sponsor:Bristol-Myers Squibb Services Unlimited Company

Neoplasm

Recruiting

Volrustomig in Patients with Unresectable Pleural Mesothelioma and Esophageal Squamous Cell Carcinoma

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years
  • Substances:Cisplatin
  • Sponsor:AstraZeneca AB

Cenegermin Eye Drops for Persistent Corneal Epithelial Defect in Patients with Persistent Corneal Epithelial Defect

Registered drug
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Cenegermin
  • Sponsor:Dompe' Farmaceutici S.p.A.

Breast cancer+4

Recruiting

Study of elacestrant and ribociclib compared to standard treatment for patients with high-risk ER+/HER2- early breast cancer

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Elacestrant
  • Sponsor:WSG Women's Cancer Study Group GmbH

A study comparing the effectiveness and safety of datopotamab deruxtecan and docetaxel in adults with advanced or metastatic non-squamous non-small cell lung cancer

Registered drugNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:Docetaxel
  • Sponsor:AstraZeneca AB
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