Karolinska Institutet

At Karolinska Institutet, clinical research in neoplasms and blood-related conditions focuses on people living with advanced cancers and those who have received cellular therapies. These studies are designed to support continued treatment, monitor safety, and evaluate how well new or ongoing cancer approaches help patients maintain disease control.

• Advanced malignancies and other difficult-to-treat cancer conditions
• Maintenance treatment for advanced ovarian cancer
• Long-term follow-up after CAR T-cell therapy

Overall, the work aims to improve treatment durability, track delayed side effects, and refine care for patients with complex cancer histories.

This research area covers both brain and vision disorders, with studies exploring new ways to diagnose and treat conditions such as Alzheimer's disease, Parkinson's disease, Dementia with Lewy Bodies, Multiple System Atrophy, and central retinal artery occlusion. The trials often focus on imaging, early detection, and testing therapies that may protect neurological or visual function.

• Alzheimer's disease and related cognitive decline
• Parkinson's disease and suspected alpha-synuclein pathology
• Central retinal artery occlusion and urgent vision-saving treatment

These studies combine treatment evaluation with advanced brain and eye imaging to better understand disease processes and improve diagnosis.

Clinical trials here also examine behavior, substance use, and related brain processes. The site investigates how interventions may influence alcohol use disorder, social behavior, and brain function, with a broader goal of improving understanding of mental health and behavior-related conditions.

• Alcohol Use Disorder and high alcohol use
• Prosocial behavior and behavioral change
• Brain mechanisms linked to addiction and decision-making

These studies are aimed at identifying better strategies for prevention, support, and treatment in behavioral health.

Research at this site also includes immune-mediated and metabolic conditions, along with disorders affecting the jaw muscles. Investigators are studying how immune-based treatments may influence latent autoimmune diabetes in adults, while other work looks at symptom relief and biological changes in myogenous temporomandibular disorders.

• Latent Autoimmune Diabetes in Adults (LADA)
• Myogenous temporomandibular disorders
• Immune and metabolic responses after treatment

These trials seek to clarify treatment effects, improve disease monitoring, and better understand how targeted interventions alter underlying biology.

Several studies at Department of Clinical Neuroscience involve healthy volunteers to support the development of new imaging tools and to compare results with patients who have neurological disease. This work helps assess how well potential brain-tracing methods can detect disease-related proteins and support future diagnostic advances.

• Brain imaging in healthy volunteers
• Evaluation of new PET tracers for alpha-synuclein and related targets
• Comparisons between healthy participants and patients with cognitive or movement disorders

The purpose of this research is to improve diagnostic precision and expand the tools available for studying brain disorders.