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Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca

Research site

Romania Strada Republicii 34-36, 400015 Cluj Napoca, Romania

  • 79 trials recruiting
  • Non-small cell lung cancer · Non-small cell lung cancer metastatic · Breast cancer
  • Adults and children

About Specializations

Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca in Cluj Napoca, Romania specialises in clinical trials of conditions such as Non-small cell lung cancer, Non-small cell lung cancer metastatic, Breast cancer, Non-small cell lung cancer stage IV, and other specialisations. This site conducts important research.

Main research areas of the site

Oncology and Solid Tumor Research

The Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca is running a broad portfolio of oncology studies focused on major neoplasms, especially breast cancer, lung cancer, prostate cancer, melanoma, and bladder cancer. These trials are designed to test new treatment options, compare them with current standards, and improve outcomes for people with advanced or early-stage disease.

  • Studies in non-small cell lung cancer are evaluating new combinations and perioperative strategies to improve survival and disease control.
  • Breast cancer research includes hormone-sensitive and HER2-negative disease, with a focus on preventing recurrence and refining long-term treatment.
  • Melanoma and cutaneous squamous cell carcinoma trials are assessing approaches to reduce relapse and strengthen immune-based care.
  • Bladder cancer studies are exploring better ways to preserve the bladder while maintaining effective cancer control.

Overall, the site supports a strong mix of treatment-comparison and recurrence-prevention research across solid tumors, with an emphasis on practical clinical benefit for patients.

Hematologic Malignancies

Research in hemic and lymphatic diseases at this hospital/clinic centers on blood cancers such as lymphoma, chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemia. The studies aim to improve disease response, extend remission, and identify more effective options for patients with relapsed, refractory, or newly diagnosed disease.

  • Non-Hodgkin lymphoma trials are comparing targeted therapies to find better control in relapsed and difficult-to-treat subtypes.
  • Multiple myeloma studies are examining maintenance and post-transplant treatment strategies to delay progression.
  • Chronic lymphocytic leukemia research includes supportive care and infection-prevention approaches alongside anti-cancer treatment.
  • Acute myeloid leukemia work is focused on safer and more effective treatment for patients who cannot receive intensive therapy.

This area reflects a strong interest in both direct cancer treatment and supportive care, helping address the needs of people living with complex hematologic cancers.

Digestive System and Liver Cancer Studies

The site also conducts research in digestive system diseases, especially liver cancer and esophageal carcinoma. These trials are mainly evaluating new immunotherapy-based and combination treatment approaches for advanced disease, with the goal of improving tumor control and survival.

  • Advanced hepatocellular carcinoma studies are testing immune-based combinations for patients who have already received prior therapy.
  • Esophageal carcinoma research is examining whether adding immunotherapy to standard treatment can improve outcomes.
  • Some studies focus on patients with advanced solid tumors to explore broader anti-cancer activity across tumor types.

These efforts show an emphasis on expanding treatment choices for hard-to-treat gastrointestinal cancers through modern systemic therapies.

Hereditary and Blood Disorder Research

In addition to cancer studies, Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca is involved in research on congenital and hereditary diseases, including haemophilia A and essential thrombocythaemia. These trials are aimed at improving long-term disease management, preventing complications, and supporting safer care for patients with chronic blood-related conditions.

  • Haemophilia A studies are evaluating long-term preventive treatment to reduce bleeding risk.
  • Essential thrombocythaemia research is focused on finding effective options for patients who cannot use standard cytoreductive therapy.
  • Some studies also address infection prevention in people with blood cancers and low antibody levels, highlighting supportive care research.

This therapeutic area adds important breadth to the site’s portfolio, linking oncology with the management of inherited and chronic hematologic conditions.

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Site location
Strada Republicii 34-36400015 Cluj NapocaRomania
Recruiting now
79 trials
Conditions studied
124

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204 clinical trials

Phase 3 Study of atebimetinib with gemcitabine and paclitaxel versus gemcitabine and paclitaxel in patients with metastatic pancreatic cancer

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Paclitaxel

Phase 3 study of ZL-1310 versus topotecan hydrochloride in patients with relapsed small cell lung cancer

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Topotecan Hydrochloride
  • Sponsor:Zai Lab (US) LLC

Study of sotorasib, panitumumab and a drug combination for patients with metastatic colorectal cancer with KRAS p.G12C mutation.

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years
  • Substances:Bevacizumab
  • Sponsor:Amgen Inc.

Study of Ifinatamab Deruxtecan and Chemotherapy for Patients with Advanced or Metastatic Esophageal Squamous Cell Carcinoma

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Docetaxel
  • Sponsor:Daiichi Sankyo Inc.

Study on the Safety and Effectiveness of BNT327 with Chemotherapy for Patients with Non-Small Cell Lung Cancer

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:BNT327
  • Sponsor:BioNTech SE

Breast cancer+1

Recruiting

Study on the Effectiveness of GP2 and Sargramostim for HER2 Positive Breast Cancer Patients with Residual Disease or High-Risk After Standard Therapy

Investigational
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Sargramostim
  • Sponsor:Greenwich LifeSciences Inc.

Study on Long-term Safety of Nivolumab and Drug Combination for Cancer Patients from Previous BMS Trials

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Bevacizumab
  • Sponsor:Bristol-Myers Squibb Services Unlimited Company

Study on the Long-term Safety and Efficacy of Pembrolizumab and Lenvatinib for Patients with Advanced Tumors

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Favezelimab
  • Sponsor:Merck Sharp & Dohme LLC

Study of LY3537982, pembrolizumab, and a drug combination for patients with advanced non-small cell lung cancer and a KRAS G12C mutation

Registered drug
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:Eli Lilly & Co.

Phase 3 Study of Subcutaneous vs Intravenous Tarlatamab with Siltuximab in Relapsed Extensive-Stage Small Cell Lung Cancer after Platinum Chemotherapy

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Siltuximab
  • Sponsor:Amgen Inc.

Phase 2 Study of Imzokitug with drug combination as First‑Line Treatment for Adults with Locally Advanced or Metastatic Non‑Small Cell Lung Cancer (NSCLC)

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:BMS-986340
  • Sponsor:Bristol-Myers Squibb Services Unlimited Company

A Randomized Double‑Blind Study of Pharmacokinetic Similarity of AVT32‑DRL_PB and Pembrolizumab in Patients with Resected Stage IIB‑C‑III Melanoma

Registered drugNo placebo
Countries:RomaniaRomania
  • Participants:18–64 years · 65+ years
  • Substances:Pembrolizumab
  • Sponsor:Alvotech Swiss AG
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