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Hospital Ruber Internacional

Verified siteinfo

Spain Calle La Maso 38, 28035 Madrid, Spain

  • 10 trials recruiting
  • Partial seizures · Severe myoclonic epilepsy of infancy · Epileptic encephalopathy
  • Adults and children

About Specializations

Hospital Ruber Internacional in Madrid, Spain specialises in clinical trials of conditions such as Partial seizures, Severe myoclonic epilepsy of infancy, Epileptic encephalopathy, Lennox-Gastaut syndrome, and other specialisations. This site conducts important research.

Main research areas of the site

Neurological Disorders – Epilepsy Research

Hospital Ruber Internacional’s neurology team is advancing the treatment of epilepsy and related encephalopathies through studies that assess safety and seizure‑reduction potential of emerging medicines.

  • Adult focal (partial onset) epilepsy
  • Refractory focal onset epilepsy
  • Dravet syndrome and Lennox‑Gastaut syndrome
  • Developmental and epileptic encephalopathies (DEE)
  • Epilepsy associated with tuberous sclerosis complex
  • KCNT1‑related developmental encephalopathy

The goal is to improve seizure control and quality of life for patients with rare and treatment‑resistant seizure disorders.

Oncology – Melanoma Immunotherapy

In the oncology unit, investigators are evaluating a biosimilar to Opdivo for patients with advanced melanoma, focusing on comparable efficacy and safety.

  • Previously untreated unresectable melanoma
  • Metastatic stage III/IV melanoma
  • First‑line immunotherapy with nivolumab biosimilar

These trials aim to broaden access to effective immunotherapy options while maintaining clinical outcomes.

Oncology – Prostate Cancer Hormone Therapy

The department conducts research on prostate cancer to determine the optimal duration of androgen deprivation therapy combined with salvage radiotherapy after surgical recurrence.

  • Recurrent prostate cancer post‑prostatectomy
  • Short‑term versus long‑term ADT
  • Salvage radiotherapy integration

Findings are expected to refine treatment protocols and improve long‑term disease‑free survival.

Neurodegenerative – Early Parkinson’s Disease

Studies at the site explore disease‑modifying strategies for Early Parkinson’s Disease, measuring impact on functional scores such as the MDS‑UPDRS.

  • Early-stage Parkinson’s patients
  • Movement Disorder Society Unified Parkinson’s Disease Rating Scale outcomes
  • Time to first worsening event

The research seeks to delay progression and maintain daily living abilities for individuals newly diagnosed with Parkinson’s.

Rare Genetic & Congenital Disorders

A dedicated program investigates therapies for congenital, hereditary and neonatal neurological conditions, targeting specific genetic mutations that drive severe seizure phenotypes.

  • KCNT1‑related developmental and epileptic encephalopathy
  • Other rare developmental encephalopathies
  • Genetically driven seizure disorders

By focusing on precision medicine, the trials aim to deliver targeted treatments that address the underlying genetic causes.

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Site location
Calle La Maso 3828035 MadridSpain
Recruiting now
10 trials
Conditions studied
19
Partner status
Verified site

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Recruiting now

Ongoing trials

Clinical trials currently enrolling participants at this site.

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Quick filters

33 clinical trials

Study on the Safety of BHV-7000 for Adults with Hard-to-Treat Focal Onset Epilepsy

InvestigationalNo placebo
Countries:SpainSpain
  • Participants:18–64 years · 65+ years
  • Substances:BHV-7000
  • Sponsor:Biohaven Therapeutics Ltd.

A Study Comparing MB11 and Nivolumab in Adults With Previously Untreated Advanced or Metastatic Melanoma

Registered drugNo placebo
Countries:SpainSpain
  • Participants:18–64 years · 65+ years
  • Substances:Nivolumab
  • Sponsor:Mabxience Research S.L.

Study of intrathecal S230815 to evaluate safety and effectiveness in children with KCNT1-related Developmental and Epileptic Encephalopathy

InvestigationalNo placebo
Countries:SpainSpain
  • Participants:0–17 years
  • Substances:S230815-2
  • Sponsor:Institut De Recherches Internationales Servier IRIS

Study on the Safety and Effectiveness of Bexicaserin for Seizures in Children and Adults with Developmental and Epileptic Encephalopathy

Investigational
Countries:SpainSpain
  • Participants:0–17 years · 18–64 years · 65+ years
  • Sponsor:Longboard Pharmaceuticals Inc.

Study on the Effects of Full Spectrum Cannabis Extract (Dronabinol, Cannabidiol) for Patients with Hard-to-Treat Epilepsy in Tuberous Sclerosis Complex

Investigational
Countries:SpainSpain
  • Participants:0–17 years · 18–64 years
  • Substances:Cannabidiol
  • Sponsor:Oils4cure S.L.

Seizure

Recruiting

Study on the Safety and Effectiveness of Alprazolam for Treating Long Seizures in Patients Aged 12 and Older

Investigational
Countries:SpainSpain
  • Participants:0–17 years · 18–64 years · 65+ years
  • Substances:Alprazolam
  • Sponsor:UCB Biopharma

Prostate cancer

Recruiting

Comparison of Short vs Long-term Hormone Therapy with Goserelin, Leuprorelin, or Triptorelin Combined with Radiation for Prostate Cancer Patients After Surgery

Registered drugNo placebo
Countries:SpainSpain
  • Participants:18–64 years
  • Substances:Bicalutamide
  • Sponsor:Instituto De Investigacion En Oncología Radioterapica FEOR

Seizure

Recruiting

Study on the Safety of Alprazolam for Treating Long Seizures in Patients Aged 12 and Older

Investigational
Countries:SpainSpain
  • Participants:0–17 years · 18–64 years · 65+ years
  • Substances:Alprazolam
  • Sponsor:UCB Biopharma

Study on Carisbamate for Treating Seizures in Children and Adults with Lennox-Gastaut Syndrome

Investigational
Countries:SpainSpain
  • Participants:0–17 years · 18–64 years
  • Substances:Carisbamate
  • Sponsor:Sk Life Science Inc.

Study on the Long-term Safety and Tolerability of Azetukalner for Patients with Epilepsy, Including Focal-onset and Primary Generalized Tonic-Clonic Seizures

InvestigationalNo placebo
Countries:SpainSpain
  • Participants:0–17 years · 18–64 years · 65+ years
  • Substances:Azetukalner
  • Sponsor:Xenon Pharmaceuticals Inc.

Parkinson's disease

Not yet recruiting

A study to test if BHV-8000 is effective and safe for adults with early Parkinson's disease

Registered drug
Countries:SpainSpain
  • Participants:18–64 years · 65+ years
  • Substances:Ioflupane (123I)
  • Sponsor:Biohaven Therapeutics Ltd.

Safety and Tolerability of Intrathecal ION337 in Patients with Dravet Syndrome

InvestigationalNo placebo
Countries:SpainSpain
  • Participants:0–17 years
  • Sponsor:Ionis Pharmaceuticals Inc.
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