Hospital De Sagunto

At Hospital De Sagunto’s intensive care unit, researchers are investigating new therapeutic options for chronic inflammatory bowel conditions.

• Long‑term efficacy of monoclonal antibody
• Safety monitoring in chronic use
• Patient‑reported outcome assessments

The primary goal is to determine whether long‑term use of a novel monoclonal antibody can improve disease control in patients with ulcerative colitis, while monitoring safety and quality of life.

The ICU team is focused on autoimmune kidney diseases, testing agents that may halt disease progression.

• Complete renal response evaluation
• Proteinuria reduction strategies
• Safety profile of oral inhibitors

Trials aim to achieve a complete renal response in individuals with lupus nephritis and to reduce protein loss in those with Immunoglobulin A nephropathy, thereby preserving kidney function.

Early‑stage breast cancer patients are enrolled to assess innovative strategies that could lower recurrence risk.

• Circulating tumor DNA as MRD marker
• Adjuvant therapy effectiveness
• Disease clearance rates

By measuring minimal residual disease through circulating tumor DNA, the study seeks to demonstrate that targeted therapy can improve outcomes for breast cancer patients.

Allergic airway disorders are being treated with novel immunotherapy approaches designed for long‑term symptom relief.

• Subcutaneous polymerised allergen extracts
• Placebo‑controlled symptom scoring
• Impact on asthma control

The investigation compares subcutaneous polymerised extracts with placebo to evaluate symptom reduction in allergic rhinitis and its effect on coexisting asthma.

Critical care research at the site aims to improve weaning strategies for patients dependent on ventilatory support.

• Predictors of successful extubation
• Non‑invasive ventilation vs high‑flow oxygen
• Standardised weaning protocols

The objective is to lower the rate of extubation failure and to define optimal protocols for transitioning from mechanical ventilation to spontaneous breathing.