Hms GmbH

The site concentrates on immune‑mediated skin disorders, aiming to test new systemic agents and assess long‑term safety for conditions such as hidradenitis suppurativa and severe plaque psoriasis.

• Upadacitinib efficacy in moderate‑to‑severe hidradenitis suppurativa
• Spesolimab long‑term safety after previous exposure
• Lutikizumab treatment of hidradenitis signs and symptoms
• Remibrutinib impact on hidradenitis activity
• LAD328 proof‑of‑concept in adult hidradenitis patients

Hms GmbH in Merzig supports these investigations with a focused team of two investigators.

Research at this centre targets psoriasis, atopic dermatitis, and actinic keratosis, evaluating both topical and oral therapies to improve skin health and reduce disease burden.

• JNJ‑77242113 for moderate‑to‑severe plaque psoriasis
• Tirbanibulin versus diclofenac for actinic keratosis on face and scalp
• Deucravacitinib compared with ustekinumab for plaque psoriasis
• Ruxolitinib 1.5% cream for hidradenitis lesions
• RO7790121 achieving EASI‑75 response in atopic dermatitis

The Merzig facility provides a patient‑friendly environment for participants across Germany.

Studies explore immune response modulation and vaccine safety in dermatologic conditions, seeking to understand how targeted therapies affect underlying immunologic pathways.

• Safety and immunologic response of SHIngrix vaccination in psoriasis or psoriatic arthritis
• Remibrutinib evaluation of cytokine inhibition in hidradenitis
• Assessment of cardiovascular safety of long‑term deucravacitinib use

Findings aim to guide clinicians on balancing efficacy with immune‑related risks.

The program investigates JAK inhibition and related pathways, focusing on sustained safety and therapeutic benefit for chronic inflammatory skin diseases.

• Long‑term extension study of oral povorcitinib in hidradenitis
• Selective treatment of oral povorcitinib rollover evaluation
• IC0624 first‑line therapy trial for mild‑to‑moderate hidradenitis

Both adult and adolescent participants are included to broaden the relevance of the results.