Helsinki University Hospital

The Medical Oncology department at Helsinki University Hospital conducts studies focused on high‑risk neuroblastoma, an aggressive pediatric cancer. Trials aim to improve long‑term event‑free survival by comparing intensified chemotherapy regimens and evaluating the benefit of added radiotherapy after surgery.

• Comparison of single versus tandem high‑dose chemotherapy
• Assessment of radiotherapy dose escalation for residual disease
• Integration of chemo‑immunotherapy for patients with insufficient metastatic response

These efforts seek to refine treatment protocols, reduce relapse rates, and ultimately enhance outcomes for children facing this challenging disease.

Researchers at Helsinki University Hospital are also investigating strategies to prevent infantile spasm syndrome in infants with underlying conditions such as tuberous sclerosis or severe vascular brain injury. The study evaluates prophylactic use of a medication to lower the incidence of epileptic spasms during the first year of life.

• Identification of infants at highest risk for spasms
• Evaluation of early preventive therapy effectiveness
• Monitoring neurodevelopmental outcomes in treated children

By focusing on early intervention, the program aims to improve neurological prognosis and quality of life for vulnerable newborns.