GHU St Anne Psychiatrie et Neurosciences

The Department of Neurology at GHU St Anne Psychiatrie et Neurosciences conducts research aimed at improving outcomes for patients with severe mood disorders, especially those who have not responded to standard treatments.

• Psilocybin‑enhanced psychotherapy
• Combination therapy with trazodone
• Proof‑of‑concept studies in depression
• Neurobiological markers of treatment response

These investigations seek to test innovative therapeutic strategies that could provide rapid relief of depressive symptoms and deepen understanding of the brain mechanisms underlying treatment resistance.

In the field of cerebrovascular disease, the site evaluates acute interventions for patients who have taken direct oral anticoagulants and experience an ischemic stroke.

• Intravenous thrombolysis with alteplase or tenecteplase
• Functional outcome measured by the modified Rankin Scale
• Safety profiling of thrombolysis in anticoagulated patients
• Optimization of emergency stroke pathways

The purpose of these studies is to determine whether a tailored IV thrombolysis strategy can improve recovery and reduce long‑term disability compared with standard care.