General Practitioners Research Institute B.V.

The General Practitioners Research Institute B.V. in Groningen is conducting studies focused on atherosclerotic cardiovascular disease and elevated lipoprotein(a). These trials aim to test new therapies that could lower major cardiac events.

• Evaluation of lepodisiran for reducing MACE-4 risk
• Assessment of cardiovascular outcomes in patients with high Lp(a)
• Exploration of novel lipid‑lowering strategies

The research seeks to improve prevention and management of heart disease within primary care settings.

Investigators at the institute are examining treatments for moderate-to-severe asthma and chronic obstructive pulmonary disease (COPD). The goal is to determine whether newer medication combinations can better control symptoms and improve health status.

• Triple therapy (ICS/LABA/LAMA) versus dual therapy in COPD patients
• Efficacy of AZD4604 in uncontrolled asthma
• Impact of eosinophil‑guided therapy on respiratory outcomes

These studies aim to enhance therapeutic options for patients whose conditions remain uncontrolled despite standard inhaled therapies.