Fakultni Nemocnice Bulovka

At Fakultni Nemocnice Bulovka in Prague, a major share of clinical research focuses on neoplasms, especially cancers of the breast, ovary, endometrium, lung, head and neck, prostate, and urinary tract. These studies are designed to test new treatment approaches, compare them with current standard care, and improve outcomes for patients with advanced or recurrent disease.

• Advanced and metastatic breast cancer, with trials exploring better maintenance and combination treatment strategies
• Ovarian cancer and related cancers, including recurrent, platinum-resistant, and high-grade forms, with a focus on improving survival
• Head and neck squamous cell carcinoma and non-small cell lung cancer, where researchers are evaluating new ways to strengthen cancer control after surgery or chemoradiation
• Prostate cancer, renal cell carcinoma, and urothelial cancer, with studies comparing emerging therapies against established options

The site’s oncology portfolio also includes research on targeted therapy, immunotherapy, and other innovative cancer treatments aimed at improving disease control and long-term outcomes.

The Dermatovenerologická klinika at Fakultni Nemocnice Bulovka is strongly involved in studies of skin and connective tissue diseases and immune system diseases. Research here covers common and difficult-to-treat conditions such as atopic dermatitis, hidradenitis suppurativa, alopecia areata, bullous pemphigoid, and chronic spontaneous urticaria, with the goal of finding more effective and better-tolerated therapies.

• Atopic dermatitis and neurodermatitis, including studies that aim to reduce itching and improve skin symptoms
• Hidradenitis suppurativa, with trials assessing new options for long-term disease control
• Alopecia areata, where researchers are evaluating treatments that may support hair regrowth
• Bullous pemphigoid and chronic spontaneous urticaria, focusing on symptom relief and sustained remission

This research reflects a broad effort to advance care for chronic inflammatory skin disorders through new therapy evaluation and better understanding of disease activity.

A substantial part of the clinical trial activity at this hospital/clinic involves female urogenital diseases and pregnancy complications, with particular emphasis on cervical cancer, endometrial cancer, ovarian cancer, fallopian tube cancer, peritoneal cancer, and endometriosis. These studies are aimed at improving treatment effectiveness, reducing recurrence, and helping define better care after surgery or standard therapy.

• Cervical cancer, including early-stage and locally advanced disease, with studies examining post-surgery and post-chemoradiation treatment strategies
• Endometrial cancer, where trials are testing maintenance and comparative treatment approaches for advanced or recurrent disease
• Ovarian and related gynecologic cancers, including platinum-resistant and high-grade disease, with research focused on extending progression-free and overall survival
• Endometriosis-related pain, reflecting interest in symptom management beyond oncology

The work in this area combines treatment optimization with efforts to improve quality of life for women facing complex gynecologic conditions.

Clinical research at the site also spans respiratory tract diseases and head and neck cancers. Investigators are studying conditions such as non-small cell lung cancer, idiopathic pulmonary fibrosis, and severe viral lung infections, alongside advanced tumors of the head and neck, with the aim of improving survival and disease control.

• Non-small cell lung cancer, including resected, locally advanced, and metastatic disease, with studies of post-surgical and combination treatment approaches
• Head and neck squamous cell carcinoma, where researchers are evaluating new strategies after chemoradiation or surgery
• Idiopathic pulmonary fibrosis, focused on better management of lung function decline
• Severe viral lung infections, with trials assessing supportive treatment to prevent worsening respiratory failure

This portfolio highlights the site’s interest in both cancer therapy and serious lung disease management, with an emphasis on improving patient outcomes in high-risk settings.

The trial program includes important work in digestive system diseases and bacterial infections and mycoses. Studies address ulcerative colitis, Clostridioides difficile infection, and colorectal cancer, reflecting a mix of inflammatory, infectious, and oncologic research aimed at better treatment and disease control.

• Ulcerative colitis, with research focused on long-term safety and symptom control in chronic bowel inflammation
• Clostridioides difficile infection, where investigators are evaluating more efficient antibiotic treatment strategies
• Colorectal cancer, included among broader oncology studies at the site
• Digestive and oral physiological phenomena, supporting research into how treatments affect gastrointestinal function

These studies show a strong interest in both inflammatory bowel disease and infectious disease management, with the practical goal of improving everyday clinical care.

Beyond the main disease groups, Fakultni Nemocnice Bulovka participates in trials across a wider range of pathological conditions and physiological research areas. This includes studies in venous ulcers, sepsis-associated acute kidney injury, and other complex conditions where the aim is to improve healing, safety, or recovery.

• Chronic venous ulcers, with research focused on wound closure and healing in difficult-to-treat cases
• Sepsis-associated acute kidney injury, reflecting interest in serious complications of critical illness
• Circulatory and respiratory physiological phenomena, supporting broader research into how disease affects body systems
• Cell and microbiological phenomena, indicating a scientific interest in underlying disease processes

These projects broaden the site’s clinical research profile and support improved supportive care alongside disease-specific treatment studies.