Fakultni Nemocnice Brno

Clinical trials in cardiovascular diseases focus on major conditions such as acute myocardial infarction, acute coronary syndrome, atrial fibrillation, and chronic heart failure. This work is aimed at testing new ways to prevent complications, improve heart protection, and support better recovery after serious cardiac events.

• Prevention of stroke and systemic embolism in atrial fibrillation
• Reducing recurrent events after myocardial infarction
• Improving treatment for heart failure with reduced ejection fraction
• Evaluating therapies for urgent bleeding control and surgical safety

These studies reflect a strong clinical focus on safer, more effective treatment strategies for patients with high-risk heart and blood vessel conditions.

The site is active in neoplasms and hemic and lymphatic diseases, with research spanning breast cancer, lung cancer, renal cell carcinoma, lymphoma, multiple myeloma, and myelodysplastic syndrome. These trials are generally designed to compare new treatment approaches with current standards and to improve disease control and survival.

• Advancing care in diffuse large B-cell lymphoma and follicular lymphoma
• Testing new options for advanced breast cancer and early breast cancer
• Evaluating therapies for multiple myeloma and myelodysplastic syndrome
• Studying treatment effectiveness in small cell lung cancer and non-small cell lung cancer

This research supports ongoing efforts to improve outcomes for patients with difficult-to-treat blood cancers and solid tumors.

Research in respiratory tract diseases includes asthma, chronic obstructive pulmonary disease, and respiratory syncytial virus prevention. The trials aim to reduce exacerbations, lower dependence on existing medicines, and strengthen protection for vulnerable groups.

• Improving control of severe eosinophilic asthma
• Reducing flare-ups in oral corticosteroid-dependent asthma
• Testing long-term management approaches for COPD
• Supporting prevention of RSV infection in high-risk infants and children

At the Internal Cardiology Clinic, these studies add to a broader portfolio that combines chronic disease management with prevention-focused care.

Several trials address immune system diseases and inflammatory disorders such as psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, and psoriasis. The main goal is to evaluate therapies that may better control symptoms, reduce inflammation, and improve daily functioning.

• Studying treatment options for psoriatic arthritis and related joint disease
• Evaluating care for moderate to severe chronic plaque psoriasis
• Assessing therapies for juvenile idiopathic arthritis
• Exploring improved control of chronic immune-driven inflammation

This area shows an emphasis on long-term symptom relief and better disease control for patients with persistent inflammatory conditions.

Clinical activity also includes nervous system diseases, multiple sclerosis, myasthenia gravis, psychoses, and imaging-related diagnostic studies. These trials are designed to improve treatment options, better understand disease behavior, and refine diagnostic evaluation.

• Assessing long-term management in multiple sclerosis
• Evaluating therapy for generalized myasthenia gravis
• Studying genetic and treatment-related factors in psychosis
• Improving magnetic resonance imaging contrast use for diagnostic assessment

These studies highlight a balanced interest in both advanced treatment and better diagnostic tools for complex neurological and psychiatric conditions.

The trial portfolio also includes female urogenital diseases, virus diseases, and blood disorders such as haemophilia A, alongside conditions like endometriosis and uveitic macular edema. Research here often focuses on symptom relief, safety, and improved quality of life.

• Investigating treatment for endometriosis-related pain
• Studying prevention and management in haemophilia A
• Evaluating care for uveitic macular edema
• Exploring protection against viral infections in at-risk populations

Across these diverse studies, Fakultni Nemocnice Brno supports clinical research aimed at practical improvements in diagnosis, prevention, and treatment.