Dermoklinika - Centrum Medyczne s.c. M. Kierstan J. Narbutt A. Lesiak

The centre conducts research on rare genetic skin disorders, aiming to evaluate the safety and effectiveness of novel topical and systemic treatments for conditions that appear at birth or in early childhood.

• Gorlin Syndrome
• Generalized Epidermolysis Bullosa Simplex
• Other congenital skin abnormalities

With 63 trials underway and a dedicated team of two investigators, Dermoklinika – Centrum Medyczne is building a knowledge base that could improve outcomes for patients with these challenging diseases.

Studies focus on autoimmune skin conditions such as lupus erythematosus and chronic urticaria, seeking new therapeutic options to reduce disease activity and enhance quality of life.

• Cutaneous Lupus Erythematosus
• Chronic Spontaneous Urticaria
• Chronic Urticaria

The trials aim to identify safer, more effective treatments for patients whose immune systems target their own skin.

A broad portfolio addresses common inflammatory dermatoses, including psoriasis, atopic dermatitis, hidradenitis suppurativa, vitiligo, and alopecia areata, with the goal of testing innovative therapies and improving disease management.

• Plaque Psoriasis
• Moderate-to-Severe Atopic Dermatitis
• Hidradenitis Suppurativa
• Nonsegmental Vitiligo
• Alopecia Areata

Long‑term safety and efficacy are evaluated across adult and pediatric populations, reflecting the centre’s commitment to comprehensive skin health.

Research explores the underlying immunological patterns that drive skin inflammation, using biomarker analysis to better understand disease pathways.

• Cytokine profiling in psoriasis
• T‑cell activity in vitiligo
• Immune cell phenotypes in atopic dermatitis

These investigations support the development of precision medicines that target specific immune signatures.

The site evaluates key signaling cascades such as JAK‑STAT and IL‑17 pathways, testing agents that modulate these processes to alleviate skin disease.

• JAK inhibition in atopic dermatitis
• IL‑17 blockade in psoriasis
• BTK inhibition in chronic urticaria

By focusing on these molecular mechanisms, the trials aim to bring targeted therapies to patients with refractory conditions.

Additional studies cover a wide range of dermatologic conditions, including pediatric and adult forms of plaque psoriasis, prurigo nodularis, and palmoplantar pustulosis, reflecting a versatile research agenda.

• Pediatric plaque psoriasis
• Adult moderate‑to‑severe plaque psoriasis
• Prurigo Nodularis
• Palmoplantar pustulosis

Located at Al. Kosciuszki 93 in Łódź, Poland, Dermoklinika – Centrum Medyczne provides a platform for diverse clinical investigations across Europe.