Coombe Women And Infants University Hospital

At Coombe Women And Infants University Hospital the Department of Paediatrics and Newborn Medicine is investigating innovative approaches for Patent Ductus Arteriosus in extremely low birth weight infants, aiming to improve survival and reduce serious complications.

• Early targeted treatment of PDA in ELBW infants
• Evaluation of paracetamol as an alternative to traditional therapies
• Reduction of intraventricular hemorrhage, necrotising enterocolitis and mortality

The programme reflects the site’s commitment to advancing neonatal cardiovascular care across Europe.

Researchers are assessing the neuroprotective potential of melatonin for infants affected by moderate‑severe hypoxic‑ischemic encephalopathy, focusing on safety and optimal dosing.

• Safety profiling of high‑dose melatonin across multiple dose levels
• Determination of therapeutic plasma melatonin concentrations
• Evaluation of ethanol exposure safety thresholds
• Identification of the recommended Phase 2 dose

This work aims to introduce effective neuroprotective strategies for newborns with severe brain injury.

The hospital’s neonatal unit is exploring cutting‑edge interventions for hypoxic‑ischemic encephalopathy, seeking to safeguard the developing nervous system of the most vulnerable infants.

• Neuroprotective treatment trials in newborns
• Biomarker monitoring for early detection of brain injury
• Long‑term developmental outcome assessments
• Integration of novel therapeutics into standard neonatal care pathways

Collaboration with pediatric neurology specialists strengthens the site’s leadership in neonatal neurological research.