Centrum gastroenterologie a hepatologie s.r.o.

The centre investigates inflammatory bowel disorders, concentrating on Crohn's disease and ulcerative colitis, with the goal of testing a novel biologic agent to achieve both induction and maintenance of clinical remission.

• Induction of clinical remission in adults
• Maintenance therapy for sustained response
• Evaluation in both adult and adolescent participants

These studies are designed to improve outcomes for patients with moderately to severely active disease and to expand therapeutic options for chronic gastrointestinal inflammation.

Research at Centrum gastroenterologie a hepatologie s.r.o. also targets the immune pathways that drive the gut inflammation, using the immune‑modulating compound icotrokinra in controlled clinical trials.

• Immune pathway inhibition strategies
• Placebo‑controlled efficacy assessment
• Comprehensive safety monitoring across age groups

Results are expected to deepen understanding of immune‑mediated disease mechanisms and may have implications for other immune system disorders beyond the gastrointestinal tract.