A Phase 3 Study of Orelabrutinib to Delay Disability Progression in Patients with Non‑Active Secondary Progressive Multiple Sclerosis
- Substances:–
France- Participants:18–64 years
- Sponsor:Zenas Biopharma (USA) LLC
Rare diseases
Investigational molecules
Locations
16 Boulevard De Bulgarie, Bp 90349, 35200 Rennes, France
Centre Hospitalier Universitaire De Rennes in Rennes, France specialises in clinical trials of conditions such as Non-small cell lung cancer, Idiopathic pulmonary fibrosis, Plasma cell myeloma, Acute myeloid leukaemia, and other specialisations. This site conducts important research.
Clinical research at Centre Hospitalier Universitaire De Rennes includes work in infectious diseases focused on Cutibacterium spp. prosthetic joint infection. The trials are designed to assess whether a treatment approach can improve safety and effectiveness for patients with this challenging joint infection.
This area reflects a practical effort to strengthen infection treatment and support better outcomes in patients with device-related bacterial infections.
The site also conducts research in ophthalmology, with trials centered on non-infectious uveitis affecting the intermediate, posterior, and pan-uveal regions. These studies aim to compare treatment options and improve control of inflammation in patients who depend on steroids.
This research is aimed at finding more effective ways to preserve vision and reduce long-term disease burden.
In the field of immune-mediated diseases, investigators at this hospital are studying uveitis as an inflammatory disorder with immune system involvement. The research focuses on whether different therapies can better control disease activity and reduce reliance on steroids.
The work highlights interest in improving care for patients with persistent inflammation through more tailored treatment approaches.
Oncology research at Centre Hospitalier Universitaire De Rennes includes studies in standard risk ALK-positive anaplastic large cell lymphoma, a childhood and adolescent cancer. The trial aims to determine whether a simpler treatment approach can still achieve strong disease control.
This work contributes to improving cancer care for younger patients while balancing effectiveness and long-term treatment burden.
Clinical trials currently enrolling participants at this site.
FrancePhase 2 Study of Nemolizumab for Skin Thickening in Adults with Systemic Sclerosis
FranceA Phase 3 Randomized Study of mRNA‑4157 plus Pembrolizumab as Adjuvant Therapy in Patients with Completely Resected Stage I Non‑Small Cell Lung Cancer
FranceOrelabrutinib in Patients with Primary Progressive Multiple Sclerosis
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FranceStudy of laroprovstat (AZD0780) to reduce heart attack, stroke and vascular complications in patients with atherosclerotic cardiovascular disease or high risk of developing it
FranceStudy of BI 1291583 tablets taken once daily for 76 weeks in adults with bronchiectasis
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