Center for Clinical and Basic Research AS

At Center for Clinical and Basic Research AS in Tallin, a major focus is cardiovascular diseases, especially atherosclerotic cardiovascular disease and adults at high risk of heart attacks or stroke. These studies aim to evaluate whether new treatments can better reduce major heart-related events and improve protection for people receiving standard lipid-lowering care.

• Reducing the risk of coronary heart disease death, myocardial infarction, and ischemic stroke
• Testing treatment effectiveness in high-risk patients without prior heart attack or stroke
• Assessing cardiovascular outcomes in people with chronic kidney disease and related risk factors

This work reflects a strong clinical interest in preventing serious cardiovascular events through better long-term disease management and outcome-focused research.

The site also conducts research in respiratory tract diseases and virus diseases, with trials centered on influenza, respiratory syncytial virus, human metapneumovirus, and cytomegalovirus infection. The main goal is to test vaccines that may improve prevention, immune response, and protection against seasonal and serious viral infections.

• Evaluating influenza vaccine safety, immune response, and protection in older adults
• Studying RSV and hMPV vaccine effectiveness for preventing lower respiratory tract disease
• Investigating a vaccine candidate to prevent primary CMV infection

These trials support efforts to strengthen infection prevention, particularly in older adults and other groups who may be more vulnerable to respiratory illness.

Another important area at the Cardiology department is immune system diseases, including primary Sjögren’s disease, plaque psoriasis, and psoriatic arthritis. The research is designed to assess whether new therapies can better control symptoms, reduce disease activity, and improve quality of life for people living with chronic inflammatory conditions.

• Measuring disease activity in primary Sjögren’s disease
• Testing treatment effectiveness for moderate to severe plaque psoriasis
• Evaluating symptom control and response in psoriatic arthritis

This portfolio highlights a clear interest in advancing more targeted options for autoimmune and inflammatory disorders.

The site’s musculoskeletal diseases and nutritional and metabolic diseases research includes osteoarthritis, postmenopausal osteoporosis, and broader bone health concerns. These trials are focused on improving joint structure, increasing bone density, and exploring therapies that may help slow disease progression or strengthen skeletal health.

• Assessing changes in knee structure in osteoarthritis
• Evaluating treatment effects on bone mineral density in postmenopausal women
• Exploring new approaches to support long-term musculoskeletal health

The research combines symptom-focused care with efforts to address underlying structural and metabolic aspects of these conditions.