Azienda Sanitaria Locale Della Provincia Di Lecce

The medical center is at the forefront of oncology research, focusing on innovative treatment strategies for metastatic colorectal cancer (mCRC). The center's research is dedicated to exploring the efficacy of combining targeted therapies with chemotherapy to improve patient outcomes.

• Metastatic Colorectal Cancer (mCRC)
• Targeted Therapy
• RAS/BRAF Mutations

By investigating the comparative effectiveness of FOLFIRI plus cetuximab versus bevacizumab, the center aims to refine first-line treatment protocols for patients with specific genetic profiles, thereby enhancing personalized medicine approaches in oncology.

In the realm of psychiatry, the center is pioneering research into the long-term management of Major Depressive Disorder (MDD). The focus is on evaluating the safety and efficacy of adjunctive therapies that complement existing antidepressant treatments.

• Major Depressive Disorder (MDD)
• Adjunctive Therapy
• Antidepressant Safety

Through the study of aticaprant as an adjunctive treatment, the center is contributing to the development of more effective therapeutic regimens that aim to improve the quality of life for individuals suffering from chronic depression.

The center is advancing the field of hematology by investigating novel treatment combinations for Chronic Lymphocytic Leukemia (CLL). The research focuses on comparing the efficacy of modern targeted therapies against traditional chemotherapy regimens.

• Chronic Lymphocytic Leukemia (CLL)
• Targeted Therapy Combinations
• Minimal Residual Disease (MRD)

By evaluating the combination of venetoclax and obinutuzumab, the center aims to establish new standards of care that offer improved outcomes for patients with CLL, particularly those without specific genetic mutations.