Azienda Ospedaliera Universitaria Senese

At Azienda Ospedaliera Universitaria Senese, clinical research in neoplasms focuses on difficult-to-treat cancers such as advanced melanoma, metastatic or unresectable melanoma, Merkel cell carcinoma, and advanced non-small cell lung cancer with KRAS G12C mutation. These studies are exploring new treatment strategies and combinations to improve outcomes for patients with limited options.

• Testing new immunotherapy approaches for melanoma and Merkel cell carcinoma
• Evaluating combination treatments for advanced NSCLC with KRAS G12C mutation
• Assessing treatment effectiveness in cancers resistant to prior therapy

This research reflects a strong interest in improving cancer care through innovative immune-based therapies and targeted treatment combinations.

The site also contributes to studies in bacterial infections and mycoses, with a focus on serious fungal diseases such as candidemia and invasive candidiasis. The goal is to compare new antifungal treatment approaches with established care to find safer and more effective options for adults with severe infection.

• Developing improved treatment options for candidemia and invasive candidiasis
• Comparing a new antifungal therapy with standard treatment
• Supporting better management of serious fungal bloodstream infections

This area highlights the hospital’s role in advancing care for complex infectious diseases where timely and effective treatment is especially important.

In cardiovascular diseases, research is centered on heart failure with mildly reduced or preserved ejection fraction, particularly in patients who also have systemic inflammation. These trials are examining whether new anti-inflammatory treatment strategies can lower the risk of serious heart-related events and improve long-term outcomes.

• Studying therapies for heart failure with HFmrEF and HFpEF
• Evaluating whether reducing inflammation can improve cardiovascular outcomes
• Testing new approaches to prevent cardiovascular death and worsening heart failure

This research area shows a clear focus on improving treatment for patients with chronic heart failure and related inflammatory risk.

The skin and connective tissue diseases portfolio includes studies in advanced melanoma, where investigators are assessing new combinations and administration methods to better support treatment delivery and effectiveness. These efforts aim to refine how modern cancer therapies are used in everyday care.

• Exploring new ways to deliver melanoma treatment
• Assessing whether treatment combinations can improve control of advanced disease
• Supporting better options for patients with advanced skin cancer

At Azienda Ospedaliera Universitaria Senese, this field connects dermatologic oncology with broader efforts to improve outcomes in aggressive skin cancers.