Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

At Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, clinical research in Eye Diseases focuses on common and vision-threatening conditions, with studies aimed at improving treatment outcomes and post-surgical recovery.

• Neovascular Age-Related Macular Degeneration
• Thyroid Eye Disease
• Postoperative inflammation after cataract surgery

This area includes trials testing new therapies and evaluating how to better control inflammation and preserve visual function.

A major part of the site’s research portfolio covers Neoplasms and blood cancers, with studies designed to assess new cancer treatments, compare them with standard care, and improve disease control.

• Breast Cancer
• Multiple Myeloma
• Acute Myeloid Leukemia
• Head and Neck Squamous Cell Carcinoma

These trials explore both targeted and immunotherapy-based approaches, aiming to extend survival and refine treatment strategies for difficult-to-treat cancers.

The site conducts extensive studies in Cardiovascular Diseases and Metabolic Disorders, reflecting a strong interest in prevention, risk reduction, and long-term disease management.

• Atherosclerotic Cardiovascular Disease
• Atrial Fibrillation
• Hypertension
• Type 2 Diabetes Mellitus
• Obesity

Research here often evaluates new therapies for lowering cardiovascular risk, improving blood sugar control, and supporting healthier weight and lipid profiles.

A substantial share of trials at this hospital address Digestive System Diseases, especially chronic liver conditions and inflammatory bowel disease, with an emphasis on symptom relief and slowing progression.

• Primary Biliary Cholangitis
• Non-Alcoholic Steatohepatitis
• Chronic Hepatitis B
• Ulcerative Colitis
• Crohn's disease

The research includes studies of new treatments for liver inflammation, fibrosis, cholestatic symptoms, and bowel inflammation.

Clinical trials in Nervous System Diseases and Immune System Diseases investigate conditions that affect movement, memory, and immune regulation, with a focus on symptom control and disease slowing.

• Alzheimer's Disease
• Amyotrophic Lateral Sclerosis
• Multiple Sclerosis
• Generalized Myasthenia Gravis
• Sjögren’s Syndrome

The studies aim to test new therapies, improve patient-reported outcomes, and better understand autoimmune and neurodegenerative disease activity.

Research at the site also spans Respiratory Tract Diseases, Virus Diseases, and inflammatory disorders, supporting efforts to improve infection control and long-term symptom management.

• Asthma
• Bronchiectasis
• Pneumonia
• Respiratory Syncytial Virus Infections
• HIV Infections

These trials are designed to evaluate treatment effectiveness, reduce exacerbations, and strengthen care for patients with chronic or recurrent respiratory and infectious diseases.

The portfolio at Policlinico Paolo Giaccone also includes specialized research in rare and complex conditions, combining Analytical, Diagnostic and Therapeutic Techniques with targeted disease-specific studies.

• Primary Myelofibrosis
• Familial Hypercholesterolemia
• Congenital Adrenal Hyperplasia
• Alpha-1 Antitrypsin Deficiency-Associated Liver Disease
• Neuroendocrine tumors

This work supports earlier diagnosis, better risk assessment, and the development of more precise therapies for uncommon and hard-to-treat diseases.