ASST Grande Ospedale Metropolitano Niguarda

At ASST Grande Ospedale Metropolitano Niguarda, a major focus is hematologic malignancies, with studies in classical Hodgkin lymphoma, non-Hodgkin lymphoma, follicular lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, and other rare B-cell cancers. These trials are designed to test new treatment combinations, improve disease control, and evaluate better options for patients whose disease has returned or is difficult to treat.

• Classical Hodgkin lymphoma and pediatric/young adult lymphomas are being studied to assess treatment response and safety of newer immunotherapy approaches.
• Follicular lymphoma, marginal zone lymphoma, and related indolent lymphomas are included in studies comparing targeted therapies and combination regimens.
• Chronic lymphocytic leukemia, Waldenström macroglobulinemia, hairy cell leukemia, and other rare B-cell disorders are being investigated to improve outcomes in relapsed or previously untreated disease.

This work reflects a strong Clinical Trial Unit expertise in blood cancers, with attention to both standard and innovative treatment strategies.

The site is active in cardiovascular diseases, including atherosclerotic cardiovascular disease, atrial fibrillation, heart failure, and stroke prevention. Research here often focuses on whether new medicines can lower the risk of major cardiac and vascular events, improve long-term protection, and offer alternatives for patients who cannot use standard therapies.

• Atherosclerotic cardiovascular disease and high-risk prevention are being studied to reduce heart attack and stroke risk.
• Atrial fibrillation trials are evaluating safer ways to prevent embolic events.
• Chronic heart failure and broader cardiovascular outcomes research aim to improve survival and reduce hospitalizations.

Several studies at ASST Grande Ospedale Metropolitano Niguarda also examine cholesterol and triglyceride disorders, linking prevention with everyday cardiovascular care.

A broad neoplasms portfolio covers colorectal cancer, lung cancer, ovarian cancer, endometrial cancer, pancreatic cancer, biliary tract cancer, and head and neck cancer. The main goal is to evaluate new immunotherapy, targeted therapy, and peri-operative treatment approaches that may improve response rates, delay progression, or make surgery more effective.

• Colorectal cancer studies include both resectable and metastatic disease, with interest in pre-operative and post-treatment strategies.
• Non-small cell lung cancer, ovarian cancer, and head and neck squamous cell carcinoma are being explored with immunotherapy-based combinations.
• Biliary tract, pancreatic, and endometrial cancers are included in trials seeking better control of advanced or recurrent disease.

This oncology research supports personalized treatment selection and more effective care for patients with difficult-to-treat solid tumors.

The research program also includes digestive system diseases and nutritional and metabolic diseases, such as Crohn's disease, primary biliary cholangitis, portal hypertension, cirrhosis, type 2 diabetes, and lipid disorders. These trials are aimed at improving symptom control, slowing disease complications, and testing therapies that may better manage long-term metabolic and liver-related conditions.

• Crohn's disease research focuses on maintaining disease control in patients who respond to treatment.
• Primary biliary cholangitis and cirrhosis with portal hypertension studies are evaluating options for itching and liver pressure-related complications.
• Type 2 diabetes, hypercholesterolemia, and hypertriglyceridemia trials are looking at better metabolic management and cardiovascular risk reduction.

The clinical work at ASST Grande Ospedale Metropolitano Niguarda connects liver care, gastroenterology, and metabolic medicine in a practical hospital setting.

Additional research spans nervous system diseases, eye diseases, and environment and public health. This includes trials in stroke, intracerebral hemorrhage, dyskinesia due to cerebral palsy, and pediatric eye anesthesia, along with studies on infectious disease and critically ill patients. The purpose is to improve everyday clinical care, support recovery, and assess practical treatment approaches in both adults and children.

• Stroke and intracerebral hemorrhage research is examining ways to improve urgent care and early outcomes.
• Dyskinesia due to cerebral palsy studies are focused on symptom relief and better movement control.
• Eye disease research includes pediatric procedures designed to make clinical exams more comfortable and effective.

The site also contributes to infectious disease and critical care research, including studies related to mpox and emergency airway management.