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Alrijne Zorggroep Stichting

Research site

The Netherlands Simon Smitweg 1, 2353 GA Leiderdorp, The Netherlands

  • 16 trials recruiting
  • Arteriosclerosis · Atrial fibrillation · Multiple sclerosis
  • Adult patients

About Specializations

Alrijne Zorggroep Stichting in Leiderdorp, The Netherlands specialises in clinical trials of conditions such as Arteriosclerosis, Atrial fibrillation, Multiple sclerosis, Obesity, and other specialisations. This site conducts important research.

Main research areas of the site

Cardiovascular Diseases

At Alrijne Zorggroep Stichting, cardiovascular research is a major focus, covering atherosclerotic cardiovascular disease, heart failure, atrial fibrillation, peripheral arterial disease, and prevention after stroke. The studies are designed to test new treatments and prevention strategies that may lower the risk of major heart and vascular events, improve rhythm control, and support better long-term outcomes for people with complex cardiovascular conditions.

  • Testing therapies that reduce the risk of heart attack, stroke, and cardiovascular death
  • Improving treatment options for heart failure, atrial fibrillation, and vascular disease
  • Evaluating strategies to prevent blood clots and other vascular complications

Research in this area also includes approaches for people with obesity and chronic kidney disease, reflecting a broad effort to improve care across linked cardiometabolic conditions.

Neoplasms

The cancer research portfolio at this hospital includes studies in breast cancer, metastatic colorectal cancer, metastatic pancreatic cancer, multiple myeloma, chronic lymphocytic leukemia, and other solid tumors. These trials focus on assessing new treatment approaches, refining sequencing of therapy, and improving outcomes for patients with advanced or hard-to-treat cancers.

  • Evaluating new anti-cancer therapies for advanced breast and other solid tumors
  • Studying treatment timing and sequencing in metastatic cancers
  • Exploring personalized approaches to improve disease control and survival

Much of the work aims to better match treatment intensity to patient needs while maintaining effectiveness and quality of life.

Nervous System Diseases

Neurology research at Alrijne Zorggroep Stichting includes studies in multiple sclerosis, secondary progressive multiple sclerosis, and prevention of recurrence after cryptogenic TIA or ischemic stroke. The trials are centered on improving disease control, testing individualized treatment schedules, and evaluating whether some long-term medicines can be adjusted safely without losing effectiveness.

  • Assessing personalized treatment strategies for multiple sclerosis
  • Studying safer ways to maintain control of inflammatory neurologic disease
  • Testing whether stopping or continuing antiplatelet therapy best prevents recurrent stroke

This research aims to support more tailored care for people living with chronic neurologic conditions.

Nutritional and Metabolic Diseases

Trials in nutritional and metabolic diseases address obesity, diabetes-related ischemic ulcers, and patients with overlapping metabolic and cardiovascular risk. The main purpose is to evaluate treatments that can improve weight-related health, protect the heart and kidneys, and support healing in people with difficult-to-treat metabolic complications.

  • Testing therapies for obesity linked to heart failure and atrial fibrillation
  • Evaluating wound-related care for diabetes-associated ischemic ulcers
  • Studying treatments that may reduce combined cardiovascular and kidney risk

These studies reflect a strong interest in the connections between metabolism, vascular health, and long-term disease prevention.

Respiratory Tract Diseases

Respiratory research at this site includes work on chronic rhinosinusitis with nasal polyps. The trials are focused on improving symptom control, reducing polyp burden, and evaluating whether new targeted therapies can offer better relief for patients whose disease remains difficult to manage.

  • Testing new treatments for persistent nasal polyps and congestion
  • Evaluating symptom improvement in chronic upper airway disease
  • Exploring options for patients with inadequately controlled respiratory inflammation

Although smaller in scale than the cardiovascular program, this area adds important breadth to the site’s clinical research portfolio.

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Site location
Simon Smitweg 12353 GA LeiderdorpThe Netherlands
Recruiting now
16 trials
Conditions studied
31

More sites in LeiderdorpThe Netherlands

Recruiting now

Ongoing trials

Clinical trials currently enrolling participants at this site.

Condition
Type of trial
Recruitment status
Quick filters

39 clinical trials

Obesity+2

Recruiting

Effect of zenagamtide on major adverse cardiovascular events in overweight or obese adults with established atherosclerotic cardiovascular disease

Investigational
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years
  • Substances:POLYPEPTIDE CONSISTING OF A GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST AND AN AMYLIN RECEPTOR AGONIST, CONNECTED BY A LINKER WITH 4 GLYCINE RESIDUES, AND CONNECTED TO A C18 FATTY ACID SIDE CHAIN
  • Sponsor:Novo Nordisk A/S

Cardiac failure

Recruiting

Study on BI 690517 and Empagliflozin for Patients with Heart Failure and Preserved Ejection Fraction

Registered drug
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:BI 690517
  • Sponsor:Boehringer Ingelheim International GmbH

Effect of Lepodisiran on Coronary Plaque in Adults with Elevated Lipoprotein(a) and Established Atherosclerotic Cardiovascular Disease or High Risk for First Event

Investigational
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years
  • Substances:LY3819469 sodium
  • Sponsor:Eli Lilly & Co.

Cardiac failure+1

Recruiting

Study of Zenagamtide (NNC0487-0111) versus placebo in patients with heart failure with preserved or mildly reduced ejection fraction and obesity

Investigational
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:POLYPEPTIDE CONSISTING OF A GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST AND AN AMYLIN RECEPTOR AGONIST, CONNECTED BY A LINKER WITH 4 GLYCINE RESIDUES, AND CONNECTED TO A C18 FATTY ACID SIDE CHAIN
  • Sponsor:Novo Nordisk A/S

Study of pembrolizumab, capecitabine, or olaparib in patients with early-stage triple negative breast cancer and remaining disease after initial treatment

Registered drugNo placebo
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:Capecitabine
  • Sponsor:Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting

A study to evaluate the effectiveness and safety of remibrutinib in patients with secondary progressive multiple sclerosis

Investigational
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:Remibrutinib
  • Sponsor:Novartis Pharma AG

A study to evaluate the effect of orforglipron on cardiovascular health in adults with atherosclerotic cardiovascular disease and/or chronic kidney disease

Investigational
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:Orforglipron hemicalcium
  • Sponsor:Eli Lilly & Co.

Study on Venetoclax, Obinutuzumab, and Pirtobrutinib for Patients with Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Registered drugNo placebo
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:Obinutuzumab
  • Sponsor:University Of Cologne

Study on Low-Dose Colchicine for Patients with Peripheral Artery Disease to Reduce Cardiovascular Risks

Registered drug
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:Colchicine
  • Sponsor:Hamilton Health Sciences Corporation

Study on Stopping or Continuing Clopidogrel, Carbasalate Calcium, and Dipyridamole for Young Patients After Stroke Without a Known Cause

Registered drugNo placebo
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years
  • Substances:Acetylsalicylic Acid
  • Sponsor:Radboud universitair medisch centrum Stichting

Embolism venous

Recruiting

Study on Venous Thromboembolism Prevention with Enoxaparin Sodium and Drug Combination for Patients Undergoing Total Hip or Knee Replacement

Registered drugNo placebo
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:Andexanet Alfa
  • Sponsor:Leids Universitair Medisch Centrum (LUMC)

Neoplasm

Recruiting

Study on the Effects of Removing Dexamethasone from Premedication in Paclitaxel Treatment for Patients with Solid Tumors

Registered drugNo placebo
Countries:The NetherlandsThe Netherlands
  • Participants:18–64 years · 65+ years
  • Substances:Dexamethasone
  • Sponsor:Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
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