Vaborbactam

Clinical trials investigating Vaborbactam are studying how it performs in different patient groups, especially children and patients with serious infections. These studies look at safety, tolerability, treatment effect, and how the body handles the drug combination used in the trials.

Related diseases and areas:

• Sepsis
• Pyelonephritis acute
• Pseudomonas infection
• Urinary tract infection

Valaciclovir

Clinical trials investigating Valaciclovir are studying how it may help in different health problems, mainly CMV infection in pregnancy and generalized periodontitis. These studies look at outcomes such as infection control, transmission rates, and treatment response in specific patient groups. Most trials are interventional and are in Phase 2 or Phase 3.

Related diseases and areas:

• Periodontitis
• Cytomegalovirus infection
• Retinitis pigmentosa

VALACICLOVIR HYDROCHLORIDE

Clinical trials are investigating VALACICLOVIR HYDROCHLORIDE in people with HSV-2 meningitis. These studies aim to see whether treatment helps improve outcomes and how it compares with placebo. The main focus is on safety and effectiveness in adults with this infection.

Related diseases and areas:

• Pneumococcal infection
• Herpes simplex meningitis

Valiltramiprosate

This article discusses the ongoing clinical trials of Valiltramiprosate, also known as ALZ-801, for the treatment of early Alzheimer’s disease. The drug is being studied in patients aged 50-80 who carry specific genetic variants associated with increased risk of Alzheimer’s. The trials aim to evaluate the drug’s effects on various biomarkers of Alzheimer’s disease, brain volumes, and cognitive function over an extended period.

Related diseases and areas:

• Dementia Alzheimer’s type

Valine

Clinical trials investigating Valine are studying nutrition support in patients with serious illness or surgery. These studies look at outcomes such as muscle protein synthesis, muscle size, and infection risk. The target groups include chronic hemodialysis patients and people recovering from major abdominal surgery or oesophagectomy.

Related diseases and areas:

• Intestinal infarction
• Peritonitis
• Laparotomy
• Oesophagectomy
• Intestinal obstruction

Valoctocogene Roxaparvovec

This article discusses a clinical trial investigating the long-term safety and effects of Valoctocogene Roxaparvovec, also known as Roctavian or BMN 270, in patients with severe hemophilia A. The study aims to evaluate the drug’s long-term safety, its impact on bleeding rates, and its effects on patients’ quality of life. This follow-up study involves participants who have previously received the drug in other BioMarin clinical trials.

Related diseases and areas:

• Factor VIII deficiency

Valproate Semisodium

Clinical trials are investigating Valproate Semisodium in different patient groups, including older adults with severe epilepsy and people with low- to moderate-risk rectal cancer. These studies are looking at whether the treatment is effective and what outcomes it can improve in each condition. Some trials are also testing safety and the best treatment approach.

Related diseases and areas:

• Status epilepticus
• Rectal cancer

Valproic Acid

Clinical trials are studying Valproic Acid in different patient groups, including some cancers, Wolfram syndrome, and tuberous sclerosis complex. These studies are mainly checking whether Valproic Acid can improve outcomes, such as disease control, hearing, or neuropsychologic development. Most trials are phase 2 studies.

Related diseases and areas:

• Tuberous sclerosis complex
• Pancreatic carcinoma metast…
• Rectal cancer
• Wolfram syndrome
• Colorectal cancer metastatic

Valsartan

Clinical trials investigating Valsartan are studying how it may help in different heart and blood vessel conditions, and in some studies how it compares with other treatments. These trials look at safety, effectiveness, and clinical outcomes in groups such as people with heart failure, cardiomyopathy, diabetes, children and young adults with Marfan syndrome, and kidney transplant recipients.

Related diseases and areas:

• Ehlers-Danlos syndrome
• Marfan’s syndrome
• Loeys-Dietz syndrome
• Cardiac failure
• Type 2 diabetes mellitus
• Cardiac failure congestive

VAMIFEPORT TRIHYDROCHLORIDE

Clinical trials are investigating VAMIFEPORT TRIHYDROCHLORIDE in adults with HFE-related hereditary hemochromatosis, a condition linked to too much iron in the body. These studies aim to evaluate whether the treatment can improve liver iron levels and assess safety in the target patient group.

Vamorolone

Clinical trials are investigating Vamorolone in boys with Duchenne Muscular Dystrophy (DMD). These studies aim to learn about long-term safety and how well treatment works over time. The trial data here focus on children who have already taken part in earlier Vamorolone studies.

Related diseases and areas:

• Duchenne muscular dystrophy

VANADIUM OXIDE SULFATE

Clinical trials are investigating VANADIUM OXIDE SULFATE as part of patch testing for metal allergy. These studies look at how well the test works and how safe it is in people with allergic contact dermatitis, including eczema. The main goal is to compare test methods and measure agreement between them.

Related diseases and areas:

• Dermatitis atopic

Vancomycin Hydrochloride

Clinical trials are studying Vancomycin Hydrochloride in different patient groups, including people with infections, ulcerative colitis, and liver cancer. These studies look at how well it works, how safe it is, and what results matter most, such as infection control, healing, or disease response.

Related diseases and areas:

• Staphylococcal bacteraemia
• Clostridium difficile colitis
• Infection
• Colitis ulcerative
• Hepatocellular carcinoma
• Clostridium difficile infec…

Vanglusagene Ensiparvovec

Vanglusagene Ensiparvovec, also known as SPK-3006, is an investigational gene therapy being studied for the treatment of Late-Onset Pompe Disease (LOPD). This article discusses the ongoing clinical trials evaluating the safety, tolerability, and potential efficacy of this novel therapy in adult patients with LOPD. We’ll explore the key aspects of the trial, including its objectives, eligibility criteria, and expected outcomes.

Related diseases and areas:

• Glycogen storage disease ty…

Vanzacaftor

Clinical trials are studying Vanzacaftor in people with cystic fibrosis. These studies look at long-term safety, tolerability, and treatment effects in children and adults, including patients 1 year of age and older. The trials are in Phase 3 and focus on how well the treatment is used over time.

Related diseases and areas:

• Cystic fibrosis

Varegacestat

Clinical trials investigating Varegacestat are studying whether it can help people with progressing desmoid tumors. The trials are designed to evaluate safety, tolerability, and effects on disease progression in affected patients. They include different study parts and compare treatment with placebo in some phases.

Related diseases and areas:

• Desmoid tumour

VARICELLA VIRUS OKA STRAIN (LIVE, ATTENUATED)

Clinical trials investigating VARICELLA VIRUS OKA STRAIN (LIVE, ATTENUATED) are looking at revaccination in children and adolescents after childhood cancer treatment. These studies mainly assess immune response, especially antibody levels, and are focused on pediatric cancer populations.

Related diseases and areas:

• Mumps
• Rubella
• Varicella zoster virus infe…
• Measles

Vascular Endothelial Growth Factor Receptor 3 Extracellular Domains 1-3 Fused To A Igg1 Fc Fragment

Clinical trials are currently underway to assess the effectiveness of a new drug called OPT-302 in treating wet age-related macular degeneration (AMD). This drug, which contains Vascular Endothelial Growth Factor Receptor 3 Extracellular Domains 1-3 Fused To A IgG1 Fc Fragment, is being tested in combination with existing treatments like ranibizumab and aflibercept. These studies aim to determine if OPT-302 can improve vision and reduce symptoms in patients with this serious eye condition.

Related diseases and areas:

• Neovascular age-related mac…
• Eye disorder

Vatiquinone

Clinical trials are investigating Vatiquinone in people with Friedreich ataxia. These studies aim to learn about long-term safety and possible benefit in patients who have already been exposed to Vatiquinone. The main focus is on safety checks, lab tests, and heart monitoring.

Related diseases and areas:

• Friedreich’s ataxia

Vb10.16

This article discusses a clinical trial investigating the use of VB10.16, a novel drug, in combination with pembrolizumab for patients with HPV16-positive head and neck squamous cell carcinoma. The study aims to assess the safety, effectiveness, and immune response of this combination therapy in patients with recurrent or metastatic cancer that cannot be treated with local therapy. The trial consists of two phases: a dose escalation phase to determine the optimal dose and a dose expansion phase to further evaluate the treatment’s efficacy and safety.

Related diseases and areas:

• Squamous cell carcinoma of …

Vedolizumab

Clinical trials investigating Vedolizumab are studying how well it works and how safe it is in people with inflammatory bowel disease. The trials include adults, children, and teenagers with ulcerative colitis, Crohn’s disease, and pouchitis, and they also look at long-term use, dose changes, and comparison with other treatments.

Related diseases and areas:

• Pouchitis
• Colitis ulcerative
• Crohn’s disease
• Acute haemorrhagic ulcerati…
• Inflammatory bowel disease

Vemircopan

Clinical trials investigating Vemircopan are studying whether it can help people with kidney diseases such as lupus nephritis and IgA nephropathy. These trials mainly look at efficacy and safety in adults with these conditions, using measures like protein in the urine.

Related diseases and areas:

• IgA nephropathy
• Lupus nephritis

Vemurafenib

Clinical trials investigating Vemurafenib are studying how well it works and how safe it is in different patient groups. The trials include people with melanoma, hairy cell leukemia, advanced cancers with BRAF changes, and children with refractory histiocytic disease. Many studies also look at response rates and other treatment outcomes.

Related diseases and areas:

• Metastatic malignant melanoma
• Neoplasm
• Triple negative breast cancer
• Hairy cell leukaemia
• Breast cancer
• Renal cell carcinoma

Venglustat

Clinical trials of Venglustat are studying whether it can help people with Fabry disease and Gaucher disease type 3. These studies look at safety, effectiveness, and patient-reported symptoms in adults and some adolescents. The trials compare Venglustat with standard treatments or placebo in different patient groups.

Related diseases and areas:

• Fabry’s disease
• Gaucher’s disease type I
• Gaucher’s disease type III

VENT-03

Clinical trials are investigating VENT-03 in adults with active cutaneous lupus erythematosus, with or without systemic lupus erythematosus. These studies aim to evaluate efficacy and safety, including changes in skin-related disease activity and immune signals in the skin.

Related diseases and areas:

• Cutaneous lupus erythematosus

Vepdegestrant

Clinical trials are studying Vepdegestrant in people with ER+, HER2– advanced or metastatic breast cancer. These studies aim to learn about safety, tolerability, and the best dose for future research. The main trial listed here tests Vepdegestrant in combination with everolimus.

Related diseases and areas:

• Breast cancer metastatic

Verapamil

Clinical trials are investigating Verapamil in several conditions, including type 1 diabetes, hypertrophic cardiomyopathy, ventricular arrhythmias, frequent premature ventricular complexes, and tuberous sclerosis complex. These studies look at safety, effectiveness, and changes in disease measures in different patient groups, including children and adults.

Related diseases and areas:

• Ventricular extrasystoles
• Hypertrophic cardiomyopathy
• Ventricular fibrillation
• Type 1 diabetes mellitus
• Tuberous sclerosis complex

VERT-002

Clinical trials are studying VERT-002 in patients with advanced solid tumors, including lung cancer with MET alterations. These studies aim to assess safety, tolerability, dose selection, and early signs of activity in people with cancer.

Related diseases and areas:

• Neoplasm
• Non-small cell lung cancer …

Vesleteplirsen

Clinical trials of Vesleteplirsen are studying people with Duchenne muscular dystrophy, especially those who may be helped by exon 51-skipping treatment. The main goals are to check safety, tolerability, and whether the treatment can increase dystrophin levels in muscle. This article summarizes the trial design, phase, target population, and key endpoints.

VG801-1

Clinical trials are investigating VG801-1 in people with biallelic ABCA4 mutation-associated retinal dystrophy. The studies are looking at safety, tolerability, and early signs of benefit, especially in vision and retinal structure. The main target group is adults with this inherited retinal disease.

VG801-2

Clinical trials are investigating VG801-2 in people with biallelic ABCA4 mutation-associated retinal dystrophy. These studies are looking at safety, tolerability, and early signs of benefit in vision and retinal function. The trial is in a small group of patients in a Phase 1/2 study.

VGA039

Clinical trials are investigating VGA039 in people with von Willebrand Disease. The studies are looking at whether VGA039 can help prevent bleeding, with a focus on safety and efficacy in adolescent and adult patients. The main trial is a Phase 3 study in people who have not previously used prophylactic von Willebrand Factor-containing concentrates.

Related diseases and areas:

• Von Willebrand’s disease

Vgl101

Clinical trials are investigating Vgl101 in people with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a type of leukoencephalopathy. These studies are looking mainly at safety, tolerability, and early signs of benefit. The trial data here include adults with this rare condition.

Related diseases and areas:

• Leukoencephalopathy

Vh4524184

Clinical trials are studying Vh4524184 in adults living with HIV-1. These studies look at antiviral activity, treatment response, and safety in treatment-naïve people, meaning people who have not yet used HIV treatment. The trials include Phase 2 research in different adult groups.

Related diseases and areas:

• HIV infection

VHB937

Clinical trials are studying VHB937 in people with amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. These Phase 2 studies aim to compare VHB937 with placebo and measure outcomes such as function, survival, and cognition in adults with these conditions.

Related diseases and areas:

• Amyotrophic lateral sclerosis
• Dementia Alzheimer’s type

Vib1116

Clinical trials are investigating Vib1116 in people with Sjögren’s syndrome. This article explains what the study aimed to evaluate, including safety and effectiveness, and which patients were included, such as those with systemic disease activity or ongoing symptoms.

Related diseases and areas:

• Sjogren’s syndrome

Vibegron

Clinical trials are investigating Vibegron in children and teens with neurogenic detrusor overactivity (NDO) who use clean intermittent catheterization (CIC). These studies look at long-term safety, efficacy, and pharmacokinetics, which means how the body handles the study drug. The main goal is to learn whether treatment improves bladder function in this patient group.

Related diseases and areas:

• Neurogenic bladder

Vibostolimab

Clinical trials are studying Vibostolimab in several cancer settings, often as part of combination treatment plans. These studies look at safety, how well the treatment works, and measures such as response rate and survival. The trials include adults, and in one study, pediatric and young adult participants.

Related diseases and areas:

• Haematological malignancy
• Non-small cell lung cancer …
• Malignant melanoma
• Renal cell carcinoma
• Colorectal cancer stage IV
• Neoplasm

Vibozilimod

Vibozilimod, also known as SCD-044, is an innovative oral medication currently undergoing clinical trials for the treatment of moderate to severe plaque psoriasis and atopic dermatitis. These phase IIb studies aim to evaluate the safety and effectiveness of Vibozilimod in patients suffering from these chronic skin conditions. The trials are designed to assess the drug’s potential to significantly improve symptoms and quality of life for individuals with these challenging dermatological disorders.

Related diseases and areas:

• Psoriasis
• Dermatitis atopic

Vibrio Alginolyticus Collagenase

This article discusses the ongoing clinical trials investigating the use of Vibrio Alginolyticus Collagenase as a potential treatment for Dupuytren’s contracture. The study is designed as a Phase I/II trial to evaluate the safety, efficacy, and optimal dosing of this new medication for patients suffering from this hand condition. The trials aim to provide valuable insights into the potential benefits and risks of using this bacterial collagenase to treat Dupuytren’s contracture, offering hope for a new non-surgical treatment option.

Related diseases and areas:

• Peyronie’s disease
• Dupuytren’s contracture

Vidofludimus Calcium

Clinical trials are studying Vidofludimus Calcium in people with relapsing multiple sclerosis, progressive multiple sclerosis, and post-COVID syndrome. These trials look at whether it can help with disease activity, relapse timing, physical function, and brain volume changes, while also checking safety and tolerability.

Related diseases and areas:

• Post-acute COVID-19 syndrome
• Relapsing-remitting multipl…
• Relapsing multiple sclerosis
• Progressive multiple sclerosis

Vidutolimod

Clinical trials are investigating Vidutolimod in adults with advanced or metastatic cancers. These studies are looking at safety and how well Vidutolimod works, often in combination with cemiplimab, in cancers such as Merkel cell carcinoma, cutaneous squamous cell carcinoma, basal cell carcinoma, triple negative breast cancer, and non-small cell lung cancer.

Related diseases and areas:

• Neoplasm malignant