Explore popular drugs in clinical trials

Check which drugs are currently being frequently studied.

See also our rare diseases glossary and popular diseases list.

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Most popular drugs

The list below features the most popular substances currently involved in ongoing clinical trials.

Drug	trials
Pembrolizumab	446
Sodium Chloride	410
Carboplatin	334
Cisplatin	278
Paclitaxel	249
Fluorouracil	230
Oxaliplatin	222
Nivolumab	208
Dexamethasone	204
Rituximab	194
Cyclophosphamide	186
Durvalumab	162
Bevacizumab	160
Capecitabine	155
Paracetamol	154
Atezolizumab	146
Docetaxel	128
Prednisone	127
Tocilizumab	124
Prednisolone	119
Gemcitabine	116
Venetoclax	116
Etoposide	114
Mycophenolate Mofetil	113
Pemetrexed	112
Doxorubicin Hydrochloride	107
Lenalidomide	98
Infliximab	97
Ipilimumab	89
Folinic Acid	89
Acetylsalicylic Acid	88
Semaglutide	88
Placebo	84
Paclitaxel Albumin-Bound	83
Daratumumab	79
Cytarabine	79
Methotrexate	78
Fludarabine Phosphate	77
Calcium Folinate	76
Letrozole	72
Bortezomib	71
Olaparib	70
Gemcitabine Hydrochloride	69
Obinutuzumab	66
Azacitidine	66
Trastuzumab	65
Dapagliflozin	65
Cetuximab	64
Tacrolimus	62
Fulvestrant	62
Lenvatinib	62
Methylprednisolone	61
Irinotecan	60
Temozolomide	59
Irinotecan Hydrochloride Trihydrate	59
Vincristine Sulfate	57
Cemiplimab	56
Trastuzumab Deruxtecan	53
Enzalutamide	51
Apixaban	50
Betamethasone Sodium Phosphate	50
Dexamethasone Sodium Phosphate	49
Lidocaine Hydrochloride Monohydrate	49
Codeine Phosphate	48
Amoxicillin	47
Exemestane	46
Buclizine Hydrochloride	46
Potassium Chloride	46
Lidocaine Hydrochloride	46
Hydrocortisone	45
Anastrozole	45
Empagliflozin	45
Adalimumab	45
Ribociclib	44
Doxorubicin	43
Pertuzumab	43
Clavulanic Acid	42
Pomalidomide	42
Clopidogrel	42
Oxygen	42
Ibrutinib	41
Rivaroxaban	41
Tenofovir Alafenamide	41
Ruxolitinib	41
Abemaciclib	40
Atorvastatin	40
Bendamustine Hydrochloride	39
Carfilzomib	39
Ropivacaine Hydrochloride	39
Palbociclib	38
Trimethoprim	38
Ifosfamide	38
Metformin Hydrochloride	38
Pemetrexed Disodium	38
Propofol	38
Sulfamethoxazole	38
Dostarlimab	37
Acalabrutinib	37
Dexamethasone Phosphate	37
Linezolid	37

New drugs in trials

The list below features the new substances involved to ongoing clinical trials.

#1 VMX-C001

Clinical trials are studying VMX-C001 in people who take a Factor Xa direct oral anticoagulant and need urgent surgery or another high-bleeding-risk procedure.

2 weeks ago

#2 LIPASE

Clinical trials are investigating LIPASE, including a new lipase product compared with pancrelipase.

2 weeks ago

#3 TRIACYLGLYCEROL LIPASE

Clinical trials of TRIACYLGLYCEROL LIPASE are studying a new lipase treatment in adults with exocrine pancreatic insufficiency.

2 weeks ago

#4 IMA401

Clinical trials are investigating IMA401 in patients with recurrent and/or refractory solid tumors.

2 weeks ago

#5 ALLERGEN EXTRACTS

Clinical trials are studying BLOMIA TROPICALIS POLYMERIZED EXTRACT as part of a vaccine for dust mite and Blomia tropicalis allergy.

2 weeks ago

#6 AUR200

Clinical trials are investigating AUR200 in people with generalized myasthenia gravis.

2 weeks ago

All drugs

3
Yttrium-90

Diseases, Neoplasms

Clinical trials investigating Yttrium-90 are studying new treatment approaches in people with certain cancers, including lymphoma and neuroendocrine tumors. These studies look at safety, tolerability, dose, and how well the treatment works. The trials involve patients with non-Hodgkin lymphoma, CNS lymphoma, and gastrointestinal neuroendocrine tumors.

Related diseases and areas:
2
Zagociguat

Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Diseases

Clinical trials are investigating Zagociguat in people with MELAS, a rare mitochondrial disease that can cause fatigue, thinking problems, and stroke-like episodes. The studies are looking at safety, tolerability, and possible effects on fatigue and cognition in adults who meet the trial criteria.

Related diseases and areas:
- MELAS syndrome
1
ZALFERMIN

Diseases, Nutritional and Metabolic Diseases

Clinical trials are investigating ZALFERMIN in people with alcohol-related liver disease. These studies look at whether it can help with liver damage and liver function, and they compare it with placebo and other study drugs. The main focus is on safety and how well the treatments work in adults with this condition.

Related diseases and areas:
- Alcoholic liver disease
1
Zalunfiban

Cardiovascular Diseases, Diseases

Zalunfiban is being studied in clinical trials for people with an acute heart attack, especially STEMI. The trials are designed to check whether it improves clinical outcomes and to measure bleeding safety after a single subcutaneous injection.

Related diseases and areas:
1
ZAMPILIMAB

Diseases, Respiratory Tract Diseases

Clinical trials are investigating ZAMPILIMAB in people with idiopathic pulmonary fibrosis (IPF), a long-term lung disease that causes scarring. These studies aim to find a dose that is safe and effective, and to measure changes in lung function. The main target population is adults with IPF.

Related diseases and areas:
- Idiopathic pulmonary fibrosis
4
Zamtocabtagene Autoleucel

Diseases, Hemic and Lymphatic Diseases, Neoplasms, Skin and Connective Tissue Diseases

Clinical trials investigating Zamtocabtagene Autoleucel are studying its use in blood cancers, especially relapsed or refractory B cell lymphomas and other mature B cell neoplasms. These trials mainly look at safety, response to treatment, and long-term follow-up in adults, children, and adolescents.

Related diseases and areas:
1
Zanamivir

Diseases, Virus Diseases

Clinical trials are investigating Zanamivir in very young patients with confirmed complicated influenza infection. The study data focus on safety, tolerability, and how the body handles treatment in neonates and infants under 6 months of age. These trials also explore early clinical outcomes in hospitalized children.

Related diseases and areas:
- Influenza
11
Zanidatamab

Digestive System Diseases, Diseases, Neoplasms

Zanidatamab is being studied in several clinical trials for different cancer types, especially HER2-positive cancers. These trials look at safety, treatment effect, and how well Zanidatamab works alone or with other cancer medicines in people with advanced, metastatic, or unresectable disease.

Related diseases and areas:
27
Zanubrutinib

Diseases, Hemic and Lymphatic Diseases, Immune System Diseases, Neoplasms, Nervous System Diseases

Clinical trials are investigating Zanubrutinib in several blood cancers and other diseases. These studies look at safety, how well the treatment works, and which patients may benefit most. The trials include people with newly diagnosed, relapsed, or hard-to-treat conditions.

Related diseases and areas:
13
Zasocitinib

Digestive System Diseases, Diseases, Musculoskeletal Diseases, Skin and Connective Tissue Diseases

Clinical trials are studying Zasocitinib in several diseases, including plaque psoriasis, psoriatic arthritis, ulcerative colitis, Crohn’s disease, vitiligo, and hidradenitis suppurativa. These studies look at safety, tolerability, and how well the treatment works in adults, children, and teens, depending on the trial.

Related diseases and areas:
4
ZELENECTIDE PEVEDOTIN

Diseases, Neoplasms

Clinical trials are studying ZELENECTIDE PEVEDOTIN in several cancer types, including non-small cell lung cancer, urothelial cancer, and breast cancer. These studies look at how well it works, how safe it is, and which patients may benefit most. The trials include adults with advanced, metastatic, or NECTIN4-amplified tumors.

Related diseases and areas:
1
Zelicapavir

Diseases, Respiratory Tract Diseases

Zelicapavir clinical trials are studying whether this investigational treatment can help adults with respiratory syncytial virus (RSV) infection. The trial data focus on safety and how well the treatment works in non-hospitalized adults who are at high risk for complications.

Related diseases and areas:
- Respiratory syncytial virus…
1
Zenocutuzumab

Diseases, Neoplasms

Clinical trials are studying Zenocutuzumab in people with solid tumors, including tumors with an NRG1 fusion. These trials look at safety, tolerability, and signs of anti-tumor activity. They also measure how long responses last in different patient groups.

Related diseases and areas:
- Neoplasm
1
Zetomipzomib

Diseases, Immune System Diseases

Clinical trials are studying Zetomipzomib in people with active lupus nephritis, a kidney problem linked to autoimmune disease. These studies look at whether it is safe and whether it helps improve disease control. The main goal is to see how well it works in adults with Class III, IV, or V lupus nephritis.

Related diseases and areas:
- Lupus nephritis
3
Zibotentan

Digestive System Diseases, Diseases, Metabolism, Phenomena and Processes

Clinical trials are studying Zibotentan in people with liver cirrhosis and in people with chronic kidney disease and high proteinuria. These studies look at whether Zibotentan, alone or with dapagliflozin, can improve disease measures and safety outcomes. They include Phase 2 and Phase 3 research in different patient groups.

Related diseases and areas:
- Hepatic cirrhosis
- Chronic kidney disease
6
Ziclumeran

Cardiovascular Diseases, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Diseases

This article explores the use of Ziclumeran, a novel drug being studied in clinical trials for treating rare genetic disorders like transthyretin amyloidosis and hereditary angioedema. Ziclumeran is part of an innovative gene editing therapy approach that aims to address the underlying genetic causes of these conditions.

Related diseases and areas:
1
Zidesamtinib

Diseases, Neoplasms

Zidesamtinib, also known as NVL-520, is an innovative drug currently being studied in clinical trials for patients with advanced ROS1-positive non-small cell lung cancer (NSCLC) and other solid tumors. This highly selective ROS1 inhibitor shows potential in treating cancers with specific genetic alterations, offering hope for patients with limited treatment options.

Related diseases and areas:
- Neoplasm malignant
2
Zidovudine

Diseases, Virus Diseases

Clinical trials investigating Zidovudine are studying HIV-infected pregnant women and children. These studies look at how the treatment is handled in pregnancy and whether it helps keep HIV under control in children. They focus on measures such as drug levels, virological suppression, and infant exposure.

Related diseases and areas:
- HIV infection
3
Ziftomenib

Diseases, Hemic and Lymphatic Diseases, Neoplasms

Clinical trials are studying Ziftomenib in people with acute leukemia, including adults and children with relapsed, refractory, or newly diagnosed disease. These studies look at safety, the best dose, how the drug behaves in the body, and whether it helps with treatment outcomes.

Related diseases and areas:
- Acute myeloid leukaemia
- Acute myeloid leukaemia rec…
2
ZIGAKIBART

Diseases, Immune System Diseases

ZIGAKIBART is being studied in clinical trials for people with IgA nephropathy, a kidney disease. These trials look at whether it can change kidney findings and how safe it is over the long term. The studies include adults who have IgA nephropathy, including people who finished earlier ZIGAKIBART trials.

Related diseases and areas:
- IgA nephropathy
1
ZILEBESIRAN

Cardiovascular Diseases, Diseases

Clinical trials are studying ZILEBESIRAN in people with hypertension that is not well controlled and who also have established cardiovascular disease or high cardiovascular risk. These trials aim to see whether it can lower major heart and blood vessel events, including death, heart attack, stroke, and heart failure events.

Related diseases and areas:
- Hypertension
8
Zilovertamab Vedotin

Diseases, Neoplasms

Zilovertamab Vedotin is being studied in clinical trials for several blood cancers, mainly diffuse large B-cell lymphoma and other B-cell malignancies. These trials look at safety, how well the treatment works, and which patient groups may benefit most. Some studies also include children, teenagers, and young adults.

Related diseases and areas:
6
Ziltivekimab

Cardiovascular Diseases, Diseases

Clinical trials are investigating Ziltivekimab in several heart and blood vessel conditions. These studies look at whether it can improve outcomes such as heart failure events, major cardiovascular events, and artery inflammation in people with inflammation, chronic kidney disease, or recent heart attack.

Related diseases and areas:
4
ZILUCOPLAN

Diseases, Hormonal diseases, Immune System Diseases, Nervous System Diseases

Clinical trials of ZILUCOPLAN are studying its safety, long-term tolerability, and how it works in people with generalized myasthenia gravis. The research includes children, teens, and adults, and some studies follow participants who already took part in earlier ZILUCOPLAN trials.

Related diseases and areas:
- Myasthenia gravis
- Acromegaly
3
Zilucoplan Sodium

Diseases, Immune System Diseases, Nervous System Diseases

Zilucoplan Sodium is being studied in clinical trials as a potential treatment for generalized myasthenia gravis (gMG), a rare autoimmune disorder that causes muscle weakness. These trials aim to evaluate the safety, effectiveness, and long-term use of Zilucoplan in both adults and children with gMG. The studies explore different administration methods, including auto-injectors and prefilled syringes, to improve patient experience and ease of use.

Related diseases and areas:
- Myasthenia gravis
16
Zimberelimab

Digestive System Diseases, Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Neoplasms

Clinical trials are investigating Zimberelimab in several cancers, often in combination with other treatments. These studies look at safety, how well treatment works, and survival outcomes in adults with advanced, metastatic, or resectable disease. The target groups include people with lung, bladder, stomach, thyroid, rare cancers, breast cancer, and other solid tumors.

Related diseases and areas:
1
ZIMISLECEL

Diseases, Nutritional and Metabolic Diseases

Clinical trials are investigating ZIMISLECEL in people with type 1 diabetes and impaired hypoglycemic awareness with severe hypoglycemia. These studies aim to evaluate safety, tolerability, and efficacy, including whether some participants can become insulin independent. The trial data describe an interventional study in a small group of adults.

Related diseases and areas:
- Diabetes mellitus
- Hypoglycaemia
1
ZINC

Diseases, Nutritional and Metabolic Diseases

Clinical trials are investigating ZINC, here studied as zinc acetate, to see how different dose regimens affect copper absorption. This Phase 2 study includes healthy participants and looks at a test related to Wilson disease. The main goal is to measure whether the treatment changes copper movement in the body.
1
Zinc Acetate Dihydrate

Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Diseases, Nervous System Diseases

Clinical trials investigating Zinc Acetate Dihydrate are studying oral zinc treatment in people with GNAO1 associated disorders. The main goals are to check feasibility and safety, and to see whether patients can take the planned doses as scheduled.

Related diseases and areas:
- Neurodevelopmental disorder
1
Zinc Acexamate

Digestive System Diseases, Diseases

Clinical trials are studying Zinc Acexamate in people with advanced chronic liver disease. These studies aim to see whether it can improve prognosis and reduce serious liver-related clinical events. The main focus is on safety and benefit in adult patients with cACLD.

Related diseases and areas:
- Liver disorder
2
ZINC CHLORIDE

Diseases, Skin and Connective Tissue Diseases

Clinical trials investigating ZINC CHLORIDE are studying its use as a patch test allergen in people with allergic contact dermatitis, and in one trial, eczema. These studies aim to assess diagnostic performance, safety, and agreement between testing methods. The target population is adults or other participants with suspected metal allergy.

Related diseases and areas:
- Dermatitis atopic
1
ZINC GLUCONATE

Diseases, Neoplasms

Clinical trials of ZINC GLUCONATE are being studied as part of skin care plans in people with first-line EGFR-mutated advanced or metastatic non-small cell lung cancer. These trials look at whether enhanced dermatologic management can lower skin side effects during amivantamab and lazertinib treatment. They focus on safety and the number of skin problems in the first 12 weeks.

Related diseases and areas:
- Non-small cell lung cancer
2
Zinc Oxide

Immune System Diseases, Immune system processes

Clinical trials for Zinc Oxide are not shown in the source data provided here. The trial records available instead study dapirolizumab pegol in people with systemic lupus erythematosus, with goals such as long-term safety and treatment response. These studies focus on adults with moderately to severely active SLE.

Related diseases and areas:
- Systemic lupus erythematosus
2
Zinc Sulphate Heptahydrate

Digestive System Diseases, Diseases, Neoplasms

Clinical trials investigating “Zinc Sulphate Heptahydrate” are not listed in the source data, but the provided trials study related nutrition support after major surgery. These studies look at outcomes such as muscle loss and infection risk in adults after oesophagectomy or emergency abdominal surgery.

Related diseases and areas:
3
Zipalertinib

Diseases, Neoplasms

Zipalertinib is an investigational drug being studied in clinical trials for the treatment of advanced non-small cell lung cancer (NSCLC), particularly in patients with specific EGFR mutations. These trials aim to evaluate the safety and efficacy of Zipalertinib alone or in combination with chemotherapy, compared to standard treatments. The studies focus on patients with EGFR exon 20 insertion mutations and other uncommon EGFR mutations, offering hope for improved outcomes in this challenging subset of lung cancer patients.

Related diseases and areas:
- Non-small cell lung cancer
2
Ziprasidone

Behavior and Behavior Mechanisms, Mental Disorders

Clinical trials investigating Ziprasidone are studying its role in people with schizophrenia and related psychotic disorders. These studies look at how well it works, especially for symptoms and cognitive problems, and what outcomes change over time in different patient groups.

Related diseases and areas:
6
Zirconium (89Zr) Crefmirlimab Berdoxam

Analytical, Diagnostic and Therapeutic Techniques and Equipment, Cardiovascular Diseases, Diagnosis, Diseases, Immune system processes, Musculoskeletal Diseases, Neoplasms, Phenomena and Processes, Respiratory Tract Diseases, Skin and Connective Tissue Diseases

Zirconium (89Zr) Crefmirlimab Berdoxam is an innovative PET imaging agent being studied in various clinical trials. This radioactive tracer is designed to help visualize CD8+ T cells in the body, potentially providing valuable information about immune responses in cancer and other diseases. The following article explores the use of this agent in different clinical trials, focusing on its potential applications in cancer, rheumatoid arthritis, and giant cell arteritis.

Related diseases and areas:
2
ZIRCONIUM (89ZR) GIRENTUXIMAB

Analytical, Diagnostic and Therapeutic Techniques and Equipment, Diagnosis, Diseases, Investigative Techniques, Neoplasms, Therapeutics

ZIRCONIUM (89ZR) GIRENTUXIMAB is being studied in clinical trials to see how well it helps find tumors on PET scans. The trials focus on people with metastatic renal cell carcinoma and Von-Hippel Lindau disease, and they measure tumor detection and imaging performance.

Related diseases and areas:
- Metastatic renal cell carci…
1
Zirconium (89Zr) Patritumab Deruxtecan

Diseases, Pathological Conditions, Signs and Symptoms, Respiratory Tract Diseases

This article discusses the use of Zirconium (89Zr) Patritumab Deruxtecan in clinical trials for patients with advanced EGFR mutation-positive lung cancer. The drug is being studied to evaluate its effectiveness in targeting HER3 proteins and to assess its potential as a treatment option for patients who have progressed on previous therapies. The trials aim to optimize imaging techniques and explore correlations between drug uptake and treatment outcomes.

Related diseases and areas:
- EGFR gene mutation
- Lung neoplasm malignant
1
ZODASIRAN

Cardiovascular Diseases, Diseases

ZODASIRAN is being studied in clinical trials for people with homozygous familial hypercholesterolemia, a rare condition that causes very high LDL cholesterol. These trials are designed to evaluate how well it lowers LDL cholesterol and to compare it with placebo in adolescent and adult participants.
2
Zofenopril Calcium

Cardiovascular Diseases, Diseases, Nutritional and Metabolic Diseases

This article delves into the use of Zofenopril Calcium, an ACE inhibitor, in clinical trials for heart failure patients. We’ll examine its role in a multi-center study aimed at evaluating the efficacy and safety of a new drug, XXB750, in combination with standard heart failure treatments. The trial focuses on patients with reduced left ventricular ejection fraction and elevated NT-proBNP levels, providing valuable insights into potential new treatment options for heart failure management.

Related diseases and areas:
- Cardiac failure
- Type 2 diabetes mellitus
8
Zolbetuximab

Digestive System Diseases, Diseases, Neoplasms

Clinical trials are studying Zolbetuximab in several cancers, especially stomach, gastroesophageal junction, and pancreatic cancer. These studies look at how well it works, how safe it is, and whether it helps people live longer or keep their cancer from growing. Most trials focus on patients with CLDN18.2-positive tumors and some studies compare Zolbetuximab with standard treatment.

Related diseases and areas:
9
Zoledronic Acid

Diseases, Musculoskeletal Diseases

Clinical trials are studying Zoledronic Acid in several patient groups, including people with osteoporosis, hip fracture, primary hyperparathyroidism, chronic low back pain with Modic changes, osteogenesis imperfecta, and rotator cuff injury. These studies look at how well the treatment works, how safe it is in the trial setting, and which timing or treatment strategy may be best.

Related diseases and areas:
5
Zoledronic Acid Monohydrate

Diseases, Musculoskeletal and Neural Physiological Phenomena, Musculoskeletal Diseases, Neoplasms, Nervous System Diseases, Phenomena and Processes

Zoledronic Acid Monohydrate is a medication being studied in various clinical trials for its potential benefits in treating bone-related conditions. These trials are exploring its use in postmenopausal osteoporosis, vertebral bone metastases, osteosarcoma, and improving knee implant stability. Researchers are investigating how this drug can help strengthen bones, reduce fracture risk, and enhance treatment outcomes when combined with other therapies.

Related diseases and areas:
1
ZOLPIDEM TARTRATE

Analytical, Diagnostic and Therapeutic Techniques and Equipment, Diseases, Nervous System Diseases, Phenomena and Processes, Physiological processes, Therapeutics

ZOLPIDEM TARTRATE clinical trials are studying how some people have unusual, or paradoxical, responses to this medicine. The trial data focus on safety and effects in patients with disorders of consciousness, people with acquired vision impairment, and healthy volunteers. The goal is to better understand who responds and what changes are measured in the brain, alertness, and function.

Related diseases and areas:
- Eye disorder
7
Zongertinib

Diseases, Neoplasms

Zongertinib is being studied in several clinical trials for different cancers, especially HER2-related tumors and non-small cell lung cancer. These trials look at safety, tolerability, dose finding, and how well the treatment works in people with advanced, metastatic, or surgically removed disease.

Related diseases and areas:
1
Zopiclone

Behavioral Disciplines and Activities

Clinical trials investigating Zopiclone are studying its role in a patient group with benzodiazepine dependence and related psychiatric or addiction disorders. These studies focus on outcomes such as changes in benzodiazepine use and compare Zopiclone with other study treatments or placebo. They help show how Zopiclone is being evaluated in real research settings.

Related diseases and areas:
- Drug dependence
1
ZOREVUNERSEN SODIUM

Diseases, Nervous System Diseases

Clinical trials are studying ZOREVUNERSEN SODIUM in people with Dravet syndrome. These studies aim to evaluate safety, tolerability, and whether the treatment can reduce major motor seizures. The main trial listed here includes patients with this rare seizure disorder.

Related diseases and areas:
- Severe myoclonic epilepsy o…
1
ZUNIBERGENE ROCPARVOVEC

Diseases, Eye Diseases

Clinical trials are investigating ZUNIBERGENE ROCPARVOVEC in adults with macular neovascularization secondary to age-related macular degeneration. These studies are designed to evaluate safety, efficacy, and how long the treatment effect lasts. The available trial data focus on a late-stage study in people with nAMD.

Related diseases and areas:
- Neovascular age-related mac…

Explore popular drugs in clinical trials

Starting by letter

Most popular drugs

New drugs in trials

#1 VMX-C001

#2 LIPASE

#3 TRIACYLGLYCEROL LIPASE

#4 IMA401

#5 ALLERGEN EXTRACTS

#6 AUR200

All drugs

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