In short
Clinical trials investigating Ropivacaine are studying how it is used in different pain-control procedures. The trials look at safety and effectiveness in patients having ICU pleural drainage, cancer surgery, cardiac surgery, hemorrhoid treatment, and hallux valgus repair.
Key points
- Clinical trials of Ropivacaine are looking at pain control and recovery in several procedure settings. The studies include ICU pleural drainage, throat and neck cancer surgery, cardiac sternotomy surgery, hemorrhoid treatment, and hallux valgus repair. Most of the trials are Phase 3, which means they are testing the treatment in larger groups of patients. The main outcomes include pain scores, morphine use after surgery, breathing function, and how long numbness lasts. These trials focus on patients having specific procedures rather than on long-term disease treatment.
Trial overview
These clinical trials study Ropivacaine in different procedure settings, mainly to see how well it helps control pain and support recovery.
The listed studies are all interventional, which means the research team gives a treatment or compares approaches and then measures the result.
Most of the trials are Phase 3 studies, and one is a Low Intervention study.
Pain and anesthesia studies
One trial in intensive care studies a serratus plane block during pleural drainage, comparing Ropivacaine with local anesthesia to see how much acute pain patients feel during the procedure.
Another trial in throat and neck cancer surgery studies a superficial cervical plexus block and looks at whether Ropivacaine can reduce the amount of morphine needed during the first 24 hours after surgery.
A third study in hallux valgus repair tests ultrasound-guided ankle blocks and compares different Ropivacaine concentrations to see how long the sensory block lasts over 48 hours.
Surgery and recovery endpoints
In cardiac sternotomy surgery, one study evaluates a parastrenal block and measures whether postoperative lung function is better, using forced vital capacity at day 1 after surgery.
In hemorrhoidal disease, one completed study tested perianal infiltration during radiofrequency treatment and compared pain at 6 hours after the procedure using a visual analogue scale.
These studies focus on short-term outcomes after procedures, such as pain scores, opioid use, breathing tests, and block duration.
Who is studied in these trials
The target populations are patients having specific procedures, not a broad group of people with one long-term disease.
- Patients in intensive care who need pleural drainage and pain control during the procedure.
- Patients having throat and neck cancer surgery, where the study looks at reducing postoperative morphine use.
- Patients having cardiac sternotomy surgery, where the study checks lung function after surgery.
- Patients with hemorrhoidal disease who undergo radiofrequency treatment.
- Patients having hallux valgus repair surgery with ankle block anesthesia.
What the trials measure
The main outcomes are different in each study, but they all focus on practical results that matter to patients.
- Acute pain during pleural drainage, measured with a numerical scale.
- Amount of morphine used after surgery, including room titration and PCA use.
- Change in forced vital capacity after cardiac surgery, which shows how well the lungs are working.
- Pain score at 6 hours after hemorrhoid treatment, measured with VAS.
- Duration of sensory block after ankle block for hallux valgus repair.
These endpoints help researchers compare whether a block or infiltration technique gives better pain relief, better recovery, or longer numbness where it is needed.