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Lna043

Clinical trials are investigating Lna043 in people with symptomatic knee osteoarthritis. These studies are checking safety, tolerability, and whether Lna043 can improve knee structure compared with placebo. The main target population is adults with painful knee osteoarthritis.

Table of Contents

Trial overview

The source data includes one interventional study of Lna043 in people with symptomatic knee osteoarthritis.[1] It was a Phase 2 trial, which means it was designed to look for early signs of benefit while also checking safety and tolerability.[1]

Who participated

The study population was patients with osteoarthritis, specifically symptomatic knee osteoarthritis.[1] The trial data do not list more detailed eligibility rules, but the study clearly focused on people with symptoms in the knee.[1]

What was studied

Researchers studied Lna043 as a drug given by intraarticular use, which means it was used inside the joint.[1] The trial compared Lna043 with placebo, which is a look-alike treatment with no active study drug.[1] The main goal was to see whether Lna043 could improve knee structure in the target knee.[1]

Outcomes measured

The primary outcome was change from baseline in the knee structure.[1] More specifically, the study looked at the central medial tibiofemoral compartment, a part of the knee joint on the inner side where the thigh bone and shin bone meet.[1] The brief summary says this outcome was measured at Week 104, showing that the study followed patients for a long period.[1]

Trial status and size

The study is listed as completed.[1] It enrolled 581 participants, which makes it a fairly large Phase 2 study for a knee osteoarthritis trial.[1]

What the results focused on

The trial focused on three main questions: whether Lna043 was safe, whether people could tolerate it, and whether it changed knee structure better than placebo.[1] Because the data provided here are trial details rather than final results, the article can describe the study goals and measurements, but not a full outcome report.[1]

Trial ID Phase Condition studied Status Enrollment
NCT04864392 Phase 2 Symptomatic knee osteoarthritis Completed 581

FAQ

  • What is being studied in the Lna043 trials? The trial is studying whether Lna043 can improve knee structure in people with symptomatic knee osteoarthritis. It also looks at safety and tolerability.
  • Who can take part in the Lna043 study? The study includes patients with symptomatic knee osteoarthritis. The trial data do not give more detailed eligibility rules.
  • What phase is the Lna043 trial? The study is a Phase 2 trial. Phase 2 studies usually look at whether a treatment may work and continue to check safety.
  • What condition is Lna043 being tested for? Lna043 is being tested for osteoarthritis, specifically symptomatic knee osteoarthritis. The study focuses on the target knee.
  • What outcome is measured in the trial? The main outcome is change from baseline in knee structure. The study looks at the central medial tibiofemoral compartment, which is a part of the knee joint.

Ongoing Clinical Trials on Lna043

  • Study on the Effects of LNA043 for Patients with Knee Osteoarthritis

    Not recruiting

    2 1 1
    Investigated drugs:
    Czechia Denmark Estonia Poland Spain

Glossary

  • Osteoarthritis: A joint disease where the cartilage and other joint parts wear down over time, causing pain and stiffness.
  • Symptomatic: Having symptoms, such as pain, swelling, or stiffness.
  • Phase 2: A stage of a clinical trial that checks early signs of benefit and continues safety testing.
  • Interventional study: A study where researchers give a treatment and then measure what happens.
  • Placebo: A look-alike treatment with no active study drug, used for comparison.
  • Tolerability: How well people can take a treatment without major problems that stop its use.
  • Efficacy: How well a treatment works for the condition being studied.
  • Baseline: The starting point before treatment begins, used for comparison later.
  • Knee structure: The physical parts of the knee joint, such as bone and cartilage, that can be measured in imaging or other assessments.
  • Central medial tibiofemoral compartment: A specific part of the knee joint where the thigh bone and shin bone meet on the inner side.
  • Target knee: The knee chosen for the study assessments.

References