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It is one of the active components of Fluenz nasal spray suspension, an influenza vaccine that contains weakened live viruses.[2] The strain is part of a fixed combination product together with two other influenza strains: Influenza Virus B/AUSTRIA/1359417/2021-like strain and Influenza Virus A/VICTORIA/4897/2022 (H1N1)pdm09-like strain.[2] The vaccine is authorised as a medicine in the European Union under authorisation record EU/1/24/1816/001, held by AstraZeneca AB.[2]
As a live attenuated influenza virus, the strain is weakened so that it does not cause influenza in healthy people. When given as a nasal spray, it mimics a natural infection in the lining of the nose and throat. This stimulates the immune system to produce antibodies and immune cells that recognise the influenza virus. The strain is classified within respiratory tract diseases as a vaccine antigen.[2]
The vaccine containing this strain is given as a nasal spray suspension for intranasal use.[2] In the trials, Fluenz nasal spray was administered at a volume of 0.20 millilitres.[2] The product is not given by injection; the intramuscular comparison used a different inactivated vaccine called Vaxigrip.[2]
Two completed Phase 3 trials have studied vaccines containing this strain. The first trial, NCT05921448, enrolled 55 participants and compared nasal Fluenz with intramuscular Vaxigrip.[2] It measured antigen-activated CD4+ T-lymphocytes and mucosal antibody titres against haemagglutinin antigens at several time points before and after vaccination.[2] The second trial, 2024-513933-18-00, enrolled 20 young children and examined viral shedding of vaccine strains in nasal lining fluid after first and second doses.[1] Both trials are completed, meaning their results have been collected.
The sources provided do not include side effect information for this specific strain. Side effects for the authorised Fluenz vaccine are described in its product information, which is not part of the data supplied here.
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