In short
Clinical trials are investigating HAEMOPHILUS INFLUENZAE TYPE B POLYRIBOSYLRIBITOL PHOSPHATE CONJUGATED TO MENINGOCOCCAL PROTEIN ADSORBED ON AMORPHOUS ALUMINIUM HYDROXYPHOSPHATE SULFATE as part of a vaccine study in pregnancy and infancy. The trial looks at immune response, antibody transfer from mother to baby, and how infants respond after maternal vaccination. The target population is pregnant women and their infants.
Key points
- These clinical trials investigate HAEMOPHILUS INFLUENZAE TYPE B POLYRIBOSYLRIBITOL PHOSPHATE CONJUGATED TO MENINGOCOCCAL PROTEIN ADSORBED ON AMORPHOUS ALUMINIUM HYDROXYPHOSPHATE SULFATE in a pregnancy and infant vaccine study. The main condition studied is whooping cough, also called pertussis. The trial is Phase 3 and included pregnant women and their infants. Researchers wanted to measure antibody responses and see how maternal antibodies are passed to newborns. The study was completed and enrolled 240 participants.
Trial overview
This article covers one interventional study of HAEMOPHILUS INFLUENZAE TYPE B POLYRIBOSYLRIBITOL PHOSPHATE CONJUGATED TO MENINGOCOCCAL PROTEIN ADSORBED ON AMORPHOUS ALUMINIUM HYDROXYPHOSPHATE SULFATE that was designed around maternal and infant immunity to pertussis (whooping cough). The study was completed and enrolled 240 participants.
Who can participate
The target population was pregnant women, with follow-up of their infants after birth. The brief summary says the project aimed to study infants born to mothers immunized during pregnancy, so both the mother and baby were part of the research question.
What is being measured
The primary outcome was the magnitude of the antibody responses to pertussis vaccination. In simple terms, the researchers measured how strong the immune response was after vaccination.
The brief summary also states that the study aimed to identify predictors and potential determinants of vaccine responses in pregnant women, the transfer of maternal antibodies to the newborn, and vaccine responses in infants. A predictor is a factor that may help explain or forecast a result.
Study phase and design
This was a Phase 3 trial. Phase 3 studies are later-stage clinical trials and are often used to better understand how an intervention performs in a larger group.
The study type was interventional, which means the researchers assigned study vaccines and then measured the immune results. The interventions listed were Vaxelis and Triaxis, both given by intramuscular injection.
Results focus on immunity
The main scientific focus was not on symptoms, but on immune protection and antibody transfer between mother and baby. This makes the trial important for understanding how vaccination during pregnancy may affect both maternal and infant immune responses.
Key points for patients
This trial studied whooping cough immunity in pregnancy and infancy, with a special focus on antibodies. It included pregnant women and their infants, was in Phase 3, and ended as a completed study with 240 participants. The main outcome was the strength of the antibody response to pertussis vaccination.