Table of contents
- Trial overview
- Who is studied
- What is measured
- Trial design and phase
- What these terms mean for patients
Trial overview
The trial titled PREDONATION RENAL RESERVE is an interventional study in a living donor renal transplantation programme.[1] It is authorised and plans to include 60 participants.[1]
The study is designed to evaluate the evolution of kidney function after transplant in both the donor and the recipient.[1] The brief summary says the researchers want to understand how pre-donation kidney function and renal reserve in the donor relate to kidney function after transplantation.[1]
Who is studied
The target population is people in a living donor kidney transplant programme.[1] This means the trial involves both the person who donates the kidney and the person who receives it.[1]
The source data do not list detailed age limits, sex limits, or other entry rules.[1] Based on the trial record, the main focus is on donor-recipient pairs in renal transplantation.[1]
What is measured
The main outcome is the change in renal function in both donor and recipient after transplantation.[1] Renal function means how well the kidneys filter the blood and remove waste.[1]
Kidney function is measured with a reference test called plasma clearance of iohexol.[1] This is a standard way to check how well the kidneys clear a substance from the blood.[1]
The trial also measures renal reserve using an intravenous infusion of an amino acid solution.[1] Renal reserve is the kidney’s ability to increase its work when the body needs more filtering power.[1]
The intervention listed in the record is Nephrotect solución para perfusión, given intravascularly.[1] The trial record does not provide more detail on how this intervention is used in the study beyond its listing.[1]
Trial design and phase
This is an interventional study, which means researchers are giving a study intervention and then measuring outcomes.[1] The trial is in Phase 3, a later stage of clinical research that studies the question in a larger group of people.[1]
The status is listed as Authorised.[1] The planned enrollment is 60 participants, which suggests a focused study rather than a very large one.[1]
What these terms mean for patients
For patients, this trial is about whether kidney function changes after a living donor transplant and whether the donor’s kidney reserve before donation helps explain those changes.[1] The study uses measured lab-based tests instead of only symptoms or routine checks.[1]
Because the trial record is limited, it does not tell us the final results, detailed eligibility rules, or whether the study has finished.[1] It does show that the research is centered on donor and recipient kidney outcomes after transplantation.[1]
