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Corylus Avellana L.

Recent clinical trials are investigating the potential of Corylus Avellana L., commonly known as hazel pollen, as a component in allergen-specific immunotherapy for moderate to severe allergic rhinitis or rhinoconjunctivitis caused by house dust mite allergy. This research aims to assess the efficacy and safety of subcutaneous immunotherapy using a mixture containing Corylus Avellana L. and other tree pollens in adult patients.

Table of Contents

What is CORYLUS AVELLANA L.?

CORYLUS AVELLANA L. is the scientific name for the common hazel tree[1]. In the context of allergy testing and treatment, it specifically refers to hazel pollen, which is a common allergen that can cause allergic reactions in sensitive individuals.

Medical Use in Allergy Testing

CORYLUS AVELLANA L. is used as a component in allergy skin prick tests. These tests are designed to help diagnose allergies to various substances, including tree pollens[1]. The specific product mentioned in the clinical trial data is “HAL Allergy Prick Test Frühblühende Bäume Mischung I,” which is a solution for skin-prick testing that includes hazel pollen along with other early-blooming tree pollens.

Allergic Conditions Related to CORYLUS AVELLANA L.

While the clinical trial data doesn’t specifically focus on hazel pollen allergy, it provides information about allergic conditions that can be associated with tree pollens, including:

  • Allergic Rhinitis: This is inflammation of the nasal passages caused by an allergic reaction, leading to symptoms like sneezing, runny nose, and nasal congestion[1].
  • Allergic Rhinoconjunctivitis: This condition affects both the nose and eyes, causing symptoms in both areas[1].
  • Allergic Asthma: Some individuals with pollen allergies may also experience asthma symptoms triggered by their allergies[1].

Other Components in the Allergy Test

The allergy test solution containing CORYLUS AVELLANA L. also includes pollen from two other early-blooming trees:

  • ALNUS GLUTINOSA POLLEN: This is pollen from the alder tree[1].
  • BETULA VERRUCOSA POLLEN: This is birch tree pollen, also known as BETULA PENDULA POLLEN[1].

These pollens are combined in the test solution to help identify allergies to early-blooming trees, which often cause similar allergic reactions.

How is the Test Administered?

The allergy test using CORYLUS AVELLANA L. and other tree pollens is administered as a skin prick test. Here’s what you can expect:

  1. A small drop of the solution is placed on your skin, usually on your forearm or back[1].
  2. The skin under the drop is gently pricked or scratched.
  3. If you’re allergic to any of the pollens in the solution, you’ll develop a small, itchy bump (called a wheal) at the site within about 15-20 minutes.
  4. The size of the wheal is measured to determine the severity of your allergy.

The maximum dose for this test is typically one drop, as indicated in the clinical trial data[1].

Safety Considerations

While skin prick tests are generally safe, it’s important to be aware of potential risks:

  • The test may cause mild discomfort or itching at the test sites.
  • In rare cases, a more severe allergic reaction could occur.
  • If you have certain skin conditions, severe allergies, or are taking specific medications, you may not be eligible for this test[1].

Always discuss any concerns with your healthcare provider before undergoing allergy testing. They can provide personalized advice based on your medical history and current health status.

Aspect Details
Study Type Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study
Main Objective Assess efficacy of subcutaneous immunotherapy for house dust mite-induced allergic rhinitis/rhinoconjunctivitis
Treatment PURETHAL Mites Mixture 50,000 AUeq/mL (including Corylus Avellana L.)
Primary Endpoint Average daily Total Combined Rhinitis Score (TCRS) during last 8 weeks of treatment
Key Secondary Endpoints Total Nasal Symptom Score (TNSS), Rhinitis Medication Score (RMS), Quality of Life, Immunological effects
Treatment Duration Approximately 52 weeks
Key Inclusion Criteria Adults 18-65 years, moderate-severe HDM allergic rhinitis, positive skin prick test, specific IgE > 0.7 U/mL
Key Exclusion Criteria Severe immune disorders, active malignancies, moderate to severe asthma, previous AIT with HDM allergen

FAQ

  • What is Corylus Avellana L. and how is it being used in clinical trials? Corylus Avellana L. is hazel pollen, which is being used as part of a mixture in allergen-specific immunotherapy. In the clinical trial, it's included in a skin prick test solution along with other tree pollens to diagnose allergies and potentially treat allergic rhinitis or rhinoconjunctivitis.
  • Who can participate in this clinical trial? The trial is open to adults aged 18-65 with moderate to severe allergic rhinitis or rhinoconjunctivitis caused by house dust mite allergy. Participants must meet specific criteria, including a positive skin prick test to house dust mites and a minimum nasal symptom score.
  • What is the main goal of this clinical trial? The main goal is to assess the effectiveness of subcutaneous immunotherapy using a mixture containing tree pollens, including Corylus Avellana L., in reducing symptoms of allergic rhinitis or rhinoconjunctivitis caused by house dust mite allergy.
  • How long does the treatment in this clinical trial last? The total treatment period should be within 52 weeks (about one year). This includes an up-dosing phase followed by a maintenance phase with regular injections.
  • What are some of the key measurements used in this trial? The trial uses several measurements, including the Total Combined Rhinitis Score (TCRS), Total Nasal Symptom Score (TNSS), quality of life questionnaires, and changes in specific antibody levels (IgE, IgG, IgG4) against house dust mites.

Ongoing Clinical Trials on Corylus Avellana L.

  • Study on the Effectiveness of PURETHAL Mites for Adults with Moderate to Severe Allergic Rhinitis or Rhinoconjunctivitis Due to House Dust Mite Allergy

    Not recruiting

    3 1 1
    Investigated drugs:
    Austria Bulgaria Germany Latvia Lithuania Poland

Glossary

  • Allergic Rhinitis: An allergic reaction that causes inflammation in the nose, leading to symptoms such as sneezing, itching, and a runny or blocked nose.
  • Rhinoconjunctivitis: A condition where both the nose and eyes are affected by an allergic reaction, causing symptoms in both areas.
  • House Dust Mite (HDM): Tiny creatures that live in household dust and are a common cause of allergies and asthma.
  • Subcutaneous Immunotherapy (SCIT): A treatment for allergies where small amounts of allergens are injected under the skin to help the body build tolerance over time.
  • Corylus Avellana L.: The scientific name for hazel, a type of tree. In this context, it refers to hazel pollen used in allergy testing and treatment.
  • Skin Prick Test (SPT): A method used to test for allergies by placing a small amount of an allergen on the skin and then lightly pricking the area to see if a reaction occurs.
  • Total Combined Rhinitis Score (TCRS): A measure used to assess the severity of allergy symptoms, combining scores for nasal symptoms and medication use.
  • Immunoglobulin E (IgE): An antibody produced by the immune system in response to allergens, often elevated in people with allergies.
  • Forced Expiratory Volume 1 (FEV1): A lung function test that measures how much air a person can exhale in one second, used to assess respiratory health.
  • Nasal Provocation Test (NPT): A test where an allergen is applied directly to the nose to assess the allergic response and confirm a specific allergy.

References

  1. http://clinicaltrials.eu/trial/study-on-the-effectiveness-of-purethal-mites-for-adults-with-moderate-to-severe-allergic-rhinitis-or-rhinoconjunctivitis-due-to-house-dust-mite-allergy/