In short
Recent clinical trials are investigating the potential of Corylus Avellana L., commonly known as hazel pollen, as a component in allergen-specific immunotherapy for moderate to severe allergic rhinitis or rhinoconjunctivitis caused by house dust mite allergy. This research aims to assess the efficacy and safety of subcutaneous immunotherapy using a mixture containing Corylus Avellana L. and other tree pollens in adult patients.
At a glance
- Study Type
- Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study
- Main Objective
- Assess efficacy of subcutaneous immunotherapy for house dust mite-induced allergic rhinitis/rhinoconjunctivitis
- Treatment
- PURETHAL Mites Mixture 50,000 AUeq/mL (including Corylus Avellana L.)
- Primary Endpoint
- Average daily Total Combined Rhinitis Score (TCRS) during last 8 weeks of treatment
- Key Secondary Endpoints
- Total Nasal Symptom Score (TNSS), Rhinitis Medication Score (RMS), Quality of Life, Immunological effects
- Treatment Duration
- Approximately 52 weeks
- Key Inclusion Criteria
- Adults 18-65 years, moderate-severe HDM allergic rhinitis, positive skin prick test, specific IgE > 0.7 U/mL
- Key Exclusion Criteria
- Severe immune disorders, active malignancies, moderate to severe asthma, previous AIT with HDM allergen
What is CORYLUS AVELLANA L.?
CORYLUS AVELLANA L. is the scientific name for the common hazel tree. In the context of allergy testing and treatment, it specifically refers to hazel pollen, which is a common allergen that can cause allergic reactions in sensitive individuals.
Medical Use in Allergy Testing
CORYLUS AVELLANA L. is used as a component in allergy skin prick tests. These tests are designed to help diagnose allergies to various substances, including tree pollens. The specific product mentioned in the clinical trial data is "HAL Allergy Prick Test Frühblühende Bäume Mischung I," which is a solution for skin-prick testing that includes hazel pollen along with other early-blooming tree pollens.
Allergic Conditions Related to CORYLUS AVELLANA L.
While the clinical trial data doesn't specifically focus on hazel pollen allergy, it provides information about allergic conditions that can be associated with tree pollens, including:
- Allergic Rhinitis: This is inflammation of the nasal passages caused by an allergic reaction, leading to symptoms like sneezing, runny nose, and nasal congestion.
- Allergic Rhinoconjunctivitis: This condition affects both the nose and eyes, causing symptoms in both areas.
- Allergic Asthma: Some individuals with pollen allergies may also experience asthma symptoms triggered by their allergies.
Other Components in the Allergy Test
The allergy test solution containing CORYLUS AVELLANA L. also includes pollen from two other early-blooming trees:
- ALNUS GLUTINOSA POLLEN: This is pollen from the alder tree.
- BETULA VERRUCOSA POLLEN: This is birch tree pollen, also known as BETULA PENDULA POLLEN.
These pollens are combined in the test solution to help identify allergies to early-blooming trees, which often cause similar allergic reactions.
How is the Test Administered?
The allergy test using CORYLUS AVELLANA L. and other tree pollens is administered as a skin prick test. Here's what you can expect:
- A small drop of the solution is placed on your skin, usually on your forearm or back.
- The skin under the drop is gently pricked or scratched.
- If you're allergic to any of the pollens in the solution, you'll develop a small, itchy bump (called a wheal) at the site within about 15-20 minutes.
- The size of the wheal is measured to determine the severity of your allergy.
The maximum dose for this test is typically one drop, as indicated in the clinical trial data.
Safety Considerations
While skin prick tests are generally safe, it's important to be aware of potential risks:
- The test may cause mild discomfort or itching at the test sites.
- In rare cases, a more severe allergic reaction could occur.
- If you have certain skin conditions, severe allergies, or are taking specific medications, you may not be eligible for this test.
Always discuss any concerns with your healthcare provider before undergoing allergy testing. They can provide personalized advice based on your medical history and current health status.