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Clobetasol propionate PH.EUR. is a very strong corticosteroid. It is classified as clobetasol (ATC code D07AD01) and is authorised as a medicine in Germany, where the product ClobeGalen 500 Mikrogramm/g Shampoo is supplied by Galenpharma GmbH.[1] The substance is a chemically synthesised corticosteroid applied to the skin.
Clobetasol propionate PH.EUR. is a very strong corticosteroid medicine. It is authorised as a medicine in Germany, where the product ClobeGalen 500 Mikrogramm/g Shampoo is supplied by Galenpharma GmbH.[1] The substance is classified as clobetasol (ATC code D07AD01). Another formulation listed in UK prescribing records is a 0.05% ointment containing 150 micrograms of clobetasol propionate per gram.[2]
Clobetasol propionate is a corticosteroid. Corticosteroids work in the skin by reducing inflammation and calming overactive immune responses. This action makes them useful for treating skin reactions such as rashes, itching and irritation.
In the trial, clobetasol propionate is given as a shampoo applied to the skin (topical application).[1] UK prescribing records also list a 0.05% ointment formulation.[2]
One trial investigates clobetasol propionate as part of dermatologic management in lung cancer treatment. It is a randomised open-label Phase 2 trial with 80 participants.[1] The trial is currently authorised. It studies patients with EGFR-mutated locally advanced or metastatic non-small cell lung cancer receiving first-line amivantamab and lazertinib.[1]
The main measure is the incidence of grade 2 or higher dermatologic adverse events of interest in the first 12 weeks after starting amivantamab and lazertinib treatment.[1] The trial compares enhanced dermatologic management with standard-of-care skin management. Clobetasol propionate shampoo is one of several medicines used in the enhanced management arm, alongside other topical and oral treatments.[1]
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