In short
This article discusses the use of Ciprofloxacin Hydrochloride Monohydrate in clinical trials for treating prosthetic joint infections. The drug is being studied as part of a combination therapy in comparison with other antibiotics for patients who have undergone surgical debridement. The trial aims to evaluate the effectiveness and safety of different antibiotic regimens in managing these complex infections.
At a glance
- Trial Name
- The RiCOTTA trial
- Main Objective
- Compare targeted monotherapy with clindamycin to rifampicin/fluoroquinolones combination treatment for prosthetic joint infections
- Study Drug
- Ciprofloxacin Hydrochloride Monohydrate (as part of the fluoroquinolone group)
- Condition Studied
- Prosthetic joint infection (hip or knee)
- Primary Endpoint
- Treatment success 15 months after surgical debridement
- Secondary Endpoints
- Quality of life, adverse events, antibiotic switches, side effects, C. difficile infection, antibiotic resistance
- Treatment Duration
- 12 weeks of antibiotic treatment
- Follow-up Period
- 15 months after surgical debridement
- Drug Formulation
- Film-coated tablet
- Maximum Daily Dose
- 1000 mg
- Route of Administration
- Oral
What is Ciprofloxacin Hydrochloride Monohydrate?
Ciprofloxacin Hydrochloride Monohydrate is an active substance used in certain medications. It belongs to a class of antibiotics known as fluoroquinolones. These antibiotics work by killing bacteria or preventing their growth, making them effective against various bacterial infections.
Medical Uses
While the specific clinical trial data provided doesn't detail all the uses of Ciprofloxacin Hydrochloride Monohydrate, it's generally used to treat a variety of bacterial infections. In the context of the clinical trial mentioned, it was being considered as part of a treatment regimen for prosthetic joint infections (PJIs). PJIs are serious complications that can occur after joint replacement surgery, where bacteria infect the area around the artificial joint.
Ciprofloxacin is often used to treat infections caused by various bacteria, including those that affect the:
- Urinary tract
- Respiratory system
- Gastrointestinal system
- Skin and soft tissues
- Bones and joints (as in the case of prosthetic joint infections)
How is it Administered?
According to the information provided, Ciprofloxacin Hydrochloride Monohydrate is administered orally. The specific medication mentioned in the trial data is Ciprofloxacin-ratiopharm® 500 mg Film-coated Tablets. As the name suggests, these are film-coated tablets that are taken by mouth.
Dosage Information
The dosage of Ciprofloxacin can vary depending on the specific condition being treated and individual patient factors. However, the trial data provides some general information about dosing:
- The maximum daily dose is 1000 mg (1 gram)
- The maximum total dose amount is 84,000 mg (84 grams)
- The maximum treatment period is 12 weeks
It's crucial to note that these are maximum amounts, and actual prescribed doses may be lower. Always follow your healthcare provider's instructions regarding dosage and duration of treatment.
Alternative Names
Ciprofloxacin Hydrochloride Monohydrate is known by several other names, which may appear on medication labels or in medical literature:
- BAY-O-9867 Monohydrate
- Ciprofloxacin Monohydrochloride Monohydrate
- Ciprofloxacin Hydrochloride Hydrate
- Ciprofloxacine Hydrochloride Monohydrate
Important Considerations
While Ciprofloxacin is an effective antibiotic, there are some important points to consider:
- It's a prescription medication and should only be taken under medical supervision.
- The full course of antibiotics should be completed as prescribed, even if you start feeling better before it's finished.
- Ciprofloxacin can interact with other medications, so inform your doctor about all medicines you're taking.
- Like all antibiotics, Ciprofloxacin can potentially lead to antibiotic resistance if misused.
- It may not be suitable for everyone, including pregnant women or those with certain pre-existing conditions.
Always consult with your healthcare provider for personalized advice and information about using Ciprofloxacin Hydrochloride Monohydrate.