In short
This article discusses clinical trials investigating the use of Canis Familiaris (553), a dog hair allergen extract, in allergy testing. While the primary focus of these trials is on birch and grass pollen allergies, Canis Familiaris (553) is being used as a comparative allergen in skin prick tests. These studies aim to assess the effectiveness and safety of sublingual immunotherapy for patients with moderate to severe allergic rhinitis or rhinoconjunctivitis.
At a glance
- Study Type
- Phase II-III clinical trials
- Primary Allergens
- Birch pollen (Betula verrucosa), Grass pollen (Phleum pratense)
- Comparative Allergen
- Canis Familiaris (553) - dog hair allergen
- Treatment
- Sublingual immunotherapy
- Primary Endpoint
- Differences in Combined Symptom and Medication Score (CSMS) during peak pollen periods
- Key Inclusion Criteria
- Adults 18-65 years, moderate to severe allergic rhinitis/rhinoconjunctivitis, specific sensitization to study allergens
- Key Exclusion Criteria
- Previous immunotherapy within 5 years, severe asthma, immune system disorders
- Safety Assessments
- Monitoring of adverse reactions, lung function tests (FEV1)
What is CANIS FAMILIARIS (553)?
CANIS FAMILIARIS (553) is the active substance in a medical product called "ALK-prick SQ 553 Hundehaare 10 HEP Lösung für den Pricktest". In simple terms, this is a solution used for skin prick tests to diagnose dog hair allergies. The term "CANIS FAMILIARIS" is the scientific name for domestic dogs, and "553" is likely a specific identifier for this allergen extract.
This product is also known by its synonym "553 dog hair", which makes it clear that it contains allergens from dog hair.
Medical Uses
The primary use of CANIS FAMILIARIS (553) is for diagnostic purposes, specifically to test for allergies to dog hair. It falls under the category of tests for allergic diseases. While this specific product is not a treatment, it plays a crucial role in diagnosing allergies, which is the first step in managing allergic conditions.
Allergies, including those to dog hair, can cause various symptoms such as sneezing, runny nose, itchy eyes, and in some cases, asthma. Proper diagnosis is essential for effective management and treatment of these conditions.
How It's Administered
CANIS FAMILIARIS (553) is administered as a solution for skin-prick test. In a skin prick test, a small amount of the allergen solution is placed on the skin, usually on the forearm or back. The skin is then gently pricked to allow the solution to enter the outer layer of skin. If a person is allergic to dog hair, a small, itchy bump (like a mosquito bite) will appear at the site within about 15-20 minutes.
Dosage
The maximum daily dose and maximum total dose for this product is 1 drop (Gtt). This is because the test typically only needs to be performed once to diagnose an allergy. The treatment period is listed as 1 day, indicating that the test is a one-time procedure.
Who Can Use It?
While the specific product information doesn't detail who can use this test, skin prick tests are generally safe for most people, including children and adults. However, there are some exceptions:
- People with severe allergies or a history of anaphylaxis may need special precautions
- Those with certain skin conditions might not be suitable candidates for skin prick tests
- People taking certain medications, particularly antihistamines, may need to temporarily stop these medications before the test
Precautions and Contraindications
While the product information doesn't list specific contraindications for CANIS FAMILIARIS (553), it's important to note that skin prick tests should be performed under medical supervision. Some general precautions for skin prick tests include:
- Informing your doctor about any medications you're taking
- Letting your doctor know if you have any skin conditions or are pregnant
- Being prepared to stay at the doctor's office for a short while after the test in case of any allergic reactions
It's crucial to remember that while this product is used for diagnosing dog hair allergies, it is not a treatment for allergies. If you're diagnosed with a dog hair allergy, your doctor will discuss appropriate management strategies, which may include avoiding exposure, medications, or in some cases, immunotherapy.