Ongoing Clinical Trials for Tooth Loss
Currently, there is 1 ongoing clinical trial investigating treatments for patients with tooth loss. This trial is taking place in Spain and focuses on the use of antibiotics during dental implant surgery to improve healing and reduce complications after procedures to restore missing teeth.
Clinical trial locations
Study on the Effects of Amoxicillin on Post-Surgical Complications in Patients with Tooth Loss Undergoing Implant Surgery
This clinical trial is examining how the antibiotic amoxicillin affects recovery and complications after dental implant surgery in patients who have lost teeth in the upper back part of their mouth. The surgery involves two important procedures: guided bone regeneration, which helps rebuild bone where it has been lost, and sinus floor elevation, which creates space for bone grafting by lifting the sinus membrane.
Who can participate: The trial is looking for medically healthy adults who are at least 21 years old. Participants should be non-smokers, former smokers who quit at least 5 years ago, or light smokers who smoke fewer than 10 cigarettes per day. Eligible patients must have missing teeth in the upper back areas of the mouth with reduced bone height between 3 to 5 millimeters at each implant site, requiring sinus floor elevation and the placement of up to 3 dental implants. Importantly, patients must not have allergies to amoxicillin, penicillin antibiotics, NSAIDs (pain relievers like ibuprofen), or cornstarch. They should also be free from current sinus membrane problems or acute sinusitis requiring treatment.
Who cannot participate: The trial excludes patients who are allergic to amoxicillin or any other antibiotics, as well as those with a history of severe allergic reactions to medications. Pregnant or breastfeeding women cannot participate. Patients currently taking medications that might interfere with the study treatment or those with medical conditions that would make participation unsafe are also excluded. Additionally, anyone who has participated in another clinical trial within the past 30 days, has a history of drug or alcohol abuse, or is unable to follow study procedures cannot join.
Trial focus: The main goal is to evaluate whether taking amoxicillin helps reduce complications after implant surgery compared to patients who do not take the antibiotic. Researchers will monitor how well the surgical site heals and watch for problems such as pain, swelling, bruising, bleeding, and signs of infection. They will also check for sinus-related issues like nosebleeds or nasal congestion. Patients will report their own experiences using visual analogue scores to rate symptoms. The study will track clinical signs including wound healing, implant stability, and any early implant loss to determine if the antibiotic provides benefits during the recovery period.
Investigational drug: Amoxicillin is an antibiotic that fights bacterial infections by preventing bacteria from building their protective cell walls, which leads to the destruction of the bacteria. In this trial, it is given as 500 mg capsules taken by mouth after surgery. The purpose is to reduce the risk of bacterial infections during the healing period following the complex dental procedures. By preventing infections, the medication may help patients experience fewer complications and recover more smoothly.
Summary
With only one ongoing clinical trial for tooth loss, research in this area appears focused on improving outcomes for patients undergoing dental implant surgery. The trial in Spain specifically targets a common complication in implant dentistry: the need for bone regeneration in the upper jaw when bone height is insufficient. The investigation centers on whether routine antibiotic use with amoxicillin can make a meaningful difference in patient recovery and reduce post-surgical complications. This trial reflects ongoing efforts to refine surgical protocols and medication strategies to optimize dental implant success rates for patients who have lost teeth.