Ongoing Clinical Trials for Temporomandibular Pain and Dysfunction Syndrome
There is currently 1 ongoing clinical trial investigating new treatments for temporomandibular pain and dysfunction syndrome. This trial is exploring the use of botulinum toxin injections to reduce muscle pain and improve jaw function in patients with this condition. (Also known as: Temporomandibular disorder, TMD, TMJ disorder)
Clinical trial locations
Study on Clostridium Botulinum Neurotoxin Type A for Treating Myalgia and Myofascial Pain in Patients with Temporomandibular Disorders
This clinical trial is investigating whether injections of Botulinum Toxin Type A (also known as Botulinumtoxin A) can help reduce muscle pain in people suffering from temporomandibular disorder. The condition affects the jaw joint and the muscles that control jaw movement, often causing pain in the jaw, face, and neck, as well as difficulties moving the jaw.
Main focus: The study aims to determine if injections of this muscle relaxant can effectively reduce pain levels in patients with muscle-related jaw disorders, and whether different doses of the treatment have varying effects on pain relief. Researchers will also examine how the treatment impacts quality of life, jaw function, and emotional well-being.
Investigational drug: Botulinum Toxin Type A is injected directly into specific jaw muscles—the masseter and temporal muscles, which are involved in chewing and jaw movement. This medication works by blocking the release of a chemical messenger called acetylcholine, which reduces muscle contractions and helps relieve pain.
Who can participate:
- Females aged between 18 and 45 years
- Diagnosed with myalgia (muscle pain), myofascial pain (pain in the muscles and surrounding tissue), or myofascial pain with referred pain according to specific diagnostic guidelines
- Average pain level of 3 or more on a pain scale for more than three months
- Previously received treatment for facial pain more than three months ago
- Use adequate contraception and have a negative pregnancy test
- May still participate if also experiencing disc displacement in the jaw joint, degenerative joint disease, or joint pain
Who cannot participate:
- Males are not eligible for this study
- Individuals outside the specified age range
- People with other medical conditions that might interfere with the study
- Individuals considered part of a vulnerable population requiring special protection or care
What to expect: Upon joining the study, participants will undergo an initial assessment to measure their pain levels and jaw function. They will then receive the botulinum toxin injections into their jaw muscles. Regular follow-up appointments will monitor changes in pain, jaw function, and overall quality of life. The study is expected to conclude by the end of 2025, at which point researchers will evaluate the overall effectiveness of the treatment.
Summary
Currently, only one clinical trial is actively recruiting patients with temporomandibular pain and dysfunction syndrome. This study is taking place in Sweden and focuses specifically on women aged 18 to 45 with muscle-related jaw pain. The trial is exploring an innovative approach using botulinum toxin injections to reduce pain and improve jaw function, while also investigating whether different doses produce different levels of pain relief. This research may provide valuable insights into new treatment options for people living with chronic jaw pain and related symptoms.