In short
There is currently 1 ongoing clinical trial investigating the treatment of pneumothorax, specifically focusing on pain management and recovery following pleurodesis surgery. This trial is being conducted in France and examines whether nonsteroidal anti-inflammatory drugs (NSAIDs) are as effective as other pain management options in patients undergoing this procedure.
Clinical trial locations
Study on the Effects of Ketoprofen and Drug Combination in Patients Undergoing Pleurodesis Surgery for Pneumothorax
This clinical trial focuses on improving pain management and recovery for patients undergoing pleurodesis surgery. Pneumothorax occurs when air leaks into the space between the lung and chest wall, causing the lung to collapse. Pleurodesis is a surgical procedure that helps stick the lung to the chest wall to prevent future collapse.
Main inclusion criteria: Patients eligible for this study must be 18 years old or older and have pneumothorax requiring video-exclusive surgical intervention, which may include minor lung resection. Participants must provide written or oral consent after understanding the study details. They must also be enrolled in a social security scheme. Women of childbearing potential must use highly effective contraception methods during the study, such as combined hormonal birth control, intrauterine devices, surgical procedures, or abstinence.
Main exclusion criteria: Patients who have previously undergone pleurodesis surgery for pneumothorax treatment cannot participate. Those who fall outside the specified age range or do not belong to the designated clinical trial groups are also excluded. Vulnerable populations, including individuals who may have limited ability to provide informed consent or are at higher risk of harm, cannot join the study.
Trial focus: The study aims to evaluate whether nonsteroidal anti-inflammatory drugs (NSAIDs) are as effective as other pain management treatments following pleurodesis surgery. The research examines several factors, including the duration of pleural drainage (the removal of fluid or air from the space around the lung), pain relief, and the occurrence of complications after surgery. Patients will be monitored at various intervals, with pain assessed using a numerical scale immediately after surgery and at specific hours and days following the procedure. Follow-up evaluations will occur at 1 month, 6 months, and 1 year after surgery to check for recurrence of pneumothorax and assess the overall efficiency of the surgical procedure.
Investigational drugs: The study investigates nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ketoprofen, which is administered as a solution for injection to manage inflammation and pain. Additional medications may be used during the trial, including nefopam and tramadol for pain relief through infusion or oral routes, as well as paracetamol administered orally. These medications help manage pain and support recovery following the surgical procedure. The trial will determine whether NSAIDs reduce the time needed for drainage after surgery without compromising effectiveness compared to other pain management options.
Summary
Currently, there is one active clinical trial investigating the treatment of pneumothorax, specifically addressing pain management and recovery following pleurodesis surgery. This trial is being conducted in France and focuses on evaluating whether nonsteroidal anti-inflammatory drugs, particularly ketoprofen, are as effective as other pain management options in reducing drainage time and improving patient outcomes. The study provides important insights into optimizing post-surgical care for patients undergoing this procedure, with follow-up assessments extending up to one year after surgery. The trial is expected to conclude by May 2028, and its findings may contribute to improved management strategies for pneumothorax patients.
