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2 clinical trials in this condition
France
BelgiumIn short
There are currently 2 clinical trials investigating new approaches to treating periodontitis. These studies are exploring whether vitamin D3 supplementation and antiviral medication can improve gum health when combined with standard dental treatments. The trials are being conducted in Belgium and France, focusing on adults with advanced gum disease.
This trial is investigating whether vitamin D3 supplementation can help improve gum health in people with both periodontitis and vitamin D deficiency. The study is being conducted in Belgium and will last 24 weeks.
Who can participate:
Who cannot participate:
What the study involves:
The trial is testing vitamin D3 (also called colecalciferol) as an additional treatment alongside standard non-surgical gum treatments. Participants will receive either vitamin D3 capsules (25,000 IU) or a placebo with no active ingredients. The main goal is to see if vitamin D3 can help reduce the depth of gum pockets, which are spaces that form between teeth and gums due to the disease.
Throughout the study, participants will have regular check-ups at baseline, 12 weeks, and 24 weeks. During these visits, dentists will measure pocket depth, check for bleeding when probing the gums, assess plaque levels, and monitor vitamin D levels through blood tests. The primary focus is on changes in residual pocket depths of 5mm or greater by the end of the 24-week period.
This trial is examining whether an antiviral medication called Valaciclovir can improve treatment results when added to standard dental cleaning procedures for people with generalized periodontitis. The study is taking place in France.
Who can participate:
Who cannot participate:
What the study involves:
This is a double-blind study, meaning neither participants nor researchers will know who receives the actual medication or placebo during the trial. Participants will receive either Valaciclovir tablets or placebo tablets, along with conventional non-surgical treatment called scaling and root planing. This standard treatment involves deep cleaning of teeth and gums to remove plaque and tartar buildup, helping gums reattach to teeth.
The study treatment period lasts 28 days, with a follow-up visit two months after the dental cleaning procedure. During visits, dental professionals will measure the depth of periodontal pockets using a special probe, check for bleeding when probing, assess plaque levels, and evaluate clinical attachment levels. The main goal is to determine whether adding the antiviral medication provides better outcomes than standard treatment alone. The study will also assess how the treatment affects quality of life using a questionnaire.
Currently, there are two clinical trials exploring innovative approaches to treating advanced periodontitis. These studies are distributed across Western Europe, with one trial in Belgium and one in France. Both trials focus on adults with stage III or IV periodontitis and are investigating whether adding supplementary medications to standard dental treatments can improve gum health outcomes.
The Belgian study explores the potential benefits of vitamin D3 supplementation specifically for patients who also have vitamin D deficiency, running over a 24-week period. The French study takes a different approach by testing an antiviral medication called Valaciclovir over a shorter 28-day treatment period with follow-up at two months. Both trials use rigorous scientific methods, including placebo controls and randomization, to ensure reliable results.
These trials represent different therapeutic approaches: one focusing on nutritional supplementation to support bone and immune health, and the other investigating whether antiviral medication might help manage the infection and inflammation associated with gum disease. The studies aim to determine whether these additions to standard dental cleaning procedures can lead to better management of periodontitis and improved patient outcomes.
This guide is here to help you understand the condition. It does not replace a conversation with your doctor, who knows your situation best.
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