Ongoing Clinical Trials for Lumbosacral Radiculopathy
This article provides information about ongoing clinical trials investigating treatments for lumbosacral radiculopathy, a condition characterized by nerve pain radiating from the lower back down to the legs, often caused by a herniated disc. Currently, there is 1 active clinical trial exploring the effectiveness of Gabapentin for managing this condition. (Also known as: Lumbosacral Radiculalgia)
Clinical trial locations
Study on Gabapentin and Placebo for Short-Term Relief of Acute Lower Back Pain from Herniated Disc in Adults
This clinical trial is investigating whether Gabapentin, a medication commonly used for nerve pain, can effectively reduce pain in adults suffering from acute lumbosacral radiculopathy caused by a herniated disc. The study compares the effectiveness of Gabapentin against a placebo over a short treatment period.
Main inclusion criteria:
- Adults aged 18 years or older
- Experiencing lower back and leg pain for less than 3 months
- Pain level of 4 or higher on the Visual Analogue Scale, indicating moderate to severe pain
- Confirmed disc herniation through imaging (CT or MRI scan) performed within the last 3 months that matches the symptoms
- Able to stay in the hospital for at least 72 hours after joining the study
- Women of childbearing age must use effective contraception
- Must be part of a social security system and provide written consent
Main exclusion criteria:
- Presence of other significant medical conditions that could interfere with the study
- Currently taking medications that might affect study results
- Spine surgery within the past 6 months
- Pregnant or breastfeeding women
- History of allergic reactions to Gabapentin
- Currently participating in another clinical trial
- History of drug or alcohol abuse
- Unable to follow study procedures
Focus and goal of the trial:
The primary focus of this study is to evaluate how well Gabapentin can relieve nerve pain compared to a placebo in people with acute pain from a herniated disc. Participants will be randomly assigned to receive either Gabapentin (300 mg capsules taken orally) or a placebo. Pain levels will be measured on Days 1, 4, and 7 using the Visual Analogue Scale, which rates pain intensity from 0 to 100. The study will also monitor any side effects experienced during the first week of treatment. The goal is to determine whether Gabapentin provides meaningful short-term pain relief and to assess its safety profile in this specific condition.
Investigational drug:
Gabapentin is the medication being tested in this trial. It is an anticonvulsant medication that works by affecting how nerves send pain signals to the brain, helping to reduce nerve pain. In this study, Gabapentin is being evaluated specifically for its ability to manage acute lower back and leg pain caused by nerve root compression from a herniated disc.
Summary
Currently, there is one active clinical trial for lumbosacral radiculopathy, taking place in France. This trial focuses on evaluating Gabapentin, a medication already used for various types of nerve pain, to determine whether it can provide effective short-term relief for patients experiencing acute pain from herniated discs. The study is designed to provide clear evidence about the medication’s effectiveness by comparing it directly with a placebo and monitoring patients closely over a one-week period. This research may help healthcare providers better understand treatment options for managing acute nerve pain in the lower back and legs.
