Ongoing Clinical Trials for Bacterial Prostatitis
There is currently 1 ongoing clinical trial for bacterial prostatitis. This trial is investigating oral antibiotic treatments for acute bacterial prostatitis in adult men, comparing the effectiveness of fosfomycin, cefixime, and ciprofloxacin in resolving urinary symptoms and clearing the infection.
Clinical trial locations
Study on the Effectiveness of Fosfomycin, Cefixime, and Ciprofloxacin in Treating Acute Bacterial Prostatitis in Adult Men
This clinical trial focuses on finding the most effective oral antibiotic treatment for acute bacterial prostatitis, a sudden bacterial infection that causes inflammation of the prostate gland. The condition often leads to symptoms such as fever, painful urination, and difficulty urinating due to prostate swelling.
Main inclusion criteria:
- Must be male and at least 18 years old
- Must have a confirmed diagnosis of acute bacterial prostatitis with sudden urinary problems, a body temperature of at least 37.8°C, and presence of bacteria or white blood cells in urine
- Must have already received intravenous antibiotics for at least 24 to 96 hours before joining the trial
- Must have laboratory tests showing bacteria that are sensitive to the trial medications (ciprofloxacin, fosfomycin, or cefixime)
- Must be able to understand study requirements and likely to complete the treatment as planned
- Must be suitable for oral medication treatment without active substance abuse or severe organ disease
Main exclusion criteria:
- Patients who are not male
- Patients younger than 18 years or older than 65 years
- Patients who are part of a vulnerable population requiring special protection or care
Focus and goal of the trial:
The study aims to determine which oral antibiotic works best for treating acute bacterial prostatitis after initial intravenous treatment. Participants will be randomly assigned to receive one of three medications: fosfomycin, cefixime, or ciprofloxacin hydrochloride. The primary goal is to evaluate how effectively these antibiotics can resolve urinary symptoms and clear the infection without needing additional antibiotics.
The treatment phase involves taking the assigned medication orally for up to 20 days. Researchers will monitor the reduction of symptoms such as fever and urinary discomfort through regular check-ups. Between 6 to 10 days after treatment ends, patients will be evaluated to determine if they have achieved clinical cure, meaning their initial symptoms have been reduced and no further systemic antibiotics are needed.
Investigational drugs:
The trial is testing three antibiotics. Fosfomycin trometamol is a broad-spectrum antibiotic that works by preventing bacteria from building their protective cell walls, ultimately destroying them. Cefixime is a cephalosporin antibiotic that also inhibits bacterial cell wall synthesis, leading to bacterial cell death. Both medications are administered orally and aim to eliminate the bacteria causing the infection while alleviating symptoms such as pain and difficulty urinating. Ciprofloxacin hydrochloride is the third medication involved in the comparison.
Summary
Currently, there is one clinical trial available for patients with bacterial prostatitis, specifically focusing on acute bacterial prostatitis in adult men. The trial is being conducted in Spain and represents an important effort to compare different oral antibiotic options after initial hospital treatment with intravenous antibiotics. The study focuses on commonly used antibiotics—fosfomycin, cefixime, and ciprofloxacin—to determine which provides the most effective treatment for this painful and urgent condition. This research may help doctors make more informed decisions about which oral antibiotics to prescribe after initial hospital treatment, potentially leading to better outcomes for patients suffering from this type of prostate infection.
