In short
This article provides information about ongoing clinical trials for aortic disorder. Currently, there is 1 clinical trial studying treatments and procedures related to this condition. The trial focuses on improving anesthesia care during heart surgery for patients with various heart conditions, including aortic disorders.
Clinical trial locations
Study on Propofol and Remifentanil for Patients with Heart Disease Undergoing Cardiac Anesthesia with Cardiopulmonary Bypass
This clinical trial is examining how two important anesthesia medications work during heart surgery. The study is being conducted in Austria and focuses on patients who need heart surgery involving a heart-lung machine, also called cardiopulmonary bypass.
Main focus and goal: The trial aims to test a special prediction model called the Eleveld Pharmacokinetic Model. This model helps doctors predict how medications behave in the body during surgery. Researchers want to see if this model can accurately predict the levels of anesthesia medications in a patient's bloodstream during heart surgery. By comparing actual medication levels with predicted levels, doctors can provide safer and more effective anesthesia care.
Investigational drugs: The study tests two medications:
- Propofol – A medication that helps patients fall asleep and stay unconscious during surgery. It works by enhancing a natural brain chemical called GABA, which has calming effects. Propofol is given directly into the bloodstream through an intravenous line.
- Remifentanil – A strong painkiller that helps manage pain during surgery. It works by attaching to specific receptors in the brain that control how we feel pain. Like propofol, it is given through an intravenous line.
Who can participate: You may be eligible for this trial if you meet these criteria:
- You are scheduled for planned (non-emergency) heart surgery
- Your surgery requires the use of a heart-lung machine (cardiopulmonary bypass)
- You are between 18 and 90 years old
- You are willing to provide informed consent, meaning you understand and agree to participate after learning about the study
Who cannot participate: You cannot join this trial if you have:
- Valvular heart disease – a condition where the heart valves do not work properly
- Coronary heart disease – a condition where blood vessels supplying the heart become narrow or blocked
- Aortic disorders – problems with the main artery that carries blood from the heart to the rest of the body
During the trial, doctors will continuously monitor how deep your anesthesia is using various measurements. They will collect blood samples to measure the actual concentration of the medications and compare these with what the model predicted. The goal is to ensure the predictions fall within an acceptable range of accuracy, specifically between -20% and +20% of the actual values.
The study is expected to be completed by December 31, 2025. The information gathered will help improve how doctors use these medications during heart surgeries, potentially leading to better and safer anesthesia care for future patients.
Summary
Currently, there is one ongoing clinical trial for aortic disorder, located in Austria. This trial focuses specifically on improving anesthesia techniques during heart surgery rather than directly treating the aortic disorder itself. The study examines two widely used anesthesia medications, propofol and remifentanil, and tests whether a prediction model can accurately forecast how these drugs work in the body during complex heart procedures involving a heart-lung machine.
The trial represents an important step in refining surgical care for patients with various heart conditions, including aortic disorders. By improving the accuracy of medication dosing during surgery, researchers hope to enhance patient safety and outcomes during these critical procedures.
