In short
Currently, there is 1 ongoing clinical trial investigating new treatment approaches for anal abscess, also known as perianal abscess. This trial is exploring whether adding antibiotic therapy after surgical drainage can help prevent complications and improve outcomes for patients.
Clinical trial locations
Study on Antibiotic Treatment with Metronidazole and Ciprofloxacin for Patients with Perianal Abscess After Surgery
This trial is investigating whether adding antibiotic treatment to standard surgical drainage can help prevent the development of perianal fistulas in patients treated for perianal abscess. A perianal fistula is an abnormal connection that can sometimes form between the anal canal and the skin after an abscess, which may require further treatment.
Main inclusion criteria:
- Must be at least 18 years old
- Must be able to receive and respond to email questionnaires
- Must have a good understanding of Dutch, both reading and writing
- Must provide written informed consent
Main exclusion criteria:
- Individuals without a perianal abscess cannot participate
- Vulnerable populations who may not be able to give proper informed consent are excluded
Focus and goal:
The trial aims to determine whether using antibiotics after surgical drainage of a perianal abscess can reduce the risk of developing a perianal fistula within one year. Participants will undergo the standard surgical procedure to drain the abscess, and then will be randomly assigned to receive either antibiotic treatment or a placebo. The study will follow participants for one year to monitor whether fistulas develop, and will also assess quality of life, the need for repeat procedures, complications, hospital stays, and time until return to work. The study is expected to conclude by July 2026.
Investigational drugs:
The trial is testing two antibiotics: Metronidazole and Ciprofloxacin. Both medications are commonly used to fight bacterial infections. Each is given orally as film-coated tablets at a dose of 500 mg. These antibiotics work by targeting and eliminating bacteria that could contribute to infection and complications after surgery. Some participants will receive placebo tablets that look identical but contain no active medication, allowing researchers to compare outcomes between those who receive antibiotics and those who do not.
Summary
Currently, only one clinical trial is actively recruiting patients with anal abscess. This trial is being conducted in the Netherlands and represents an important effort to improve treatment outcomes for this painful condition. The study focuses specifically on whether antibiotic therapy with Metronidazole and Ciprofloxacin can prevent one of the most common complications following surgical treatment—the development of perianal fistulas. The trial is designed to provide clear evidence about whether adding antibiotics to standard surgical care offers meaningful benefits to patients, including reduced complications and improved quality of life. Patients interested in participating must be able to communicate in Dutch and complete electronic questionnaires as part of the follow-up process.
