Ongoing Clinical Trials for Acarodermatitis
There is currently 1 ongoing clinical trial investigating treatment options for acarodermatitis (also known as scabies). This trial is being conducted in Germany and compares two different concentrations of permethrin cream to determine which is more effective in treating this skin condition caused by mites.
Clinical trial locations
Study on Scabies Treatment Comparing 10% Permethrin Cream to 5% Permethrin Cream for Patients with Scabies
This trial is investigating whether a higher concentration of permethrin cream can provide better results for treating scabies compared to the standard treatment. Scabies is a skin condition caused by tiny mites that burrow into the skin, causing intense itching and a rash that often worsens at night.
Main inclusion criteria:
- You must have a confirmed diagnosis of scabies, verified by finding mites, their young, or their eggs under a microscope in skin samples
- You must be between 18 and 85 years old
- You must provide written consent after understanding what the study involves
- The treatment must be applied by trained specialists at the trial site
Main exclusion criteria:
- Being outside the specified age range
- Being part of a vulnerable population requiring special protection
- Having other medical conditions not related to scabies
- Currently participating in another clinical trial
- Having allergies to the study medication or similar treatments
- Being pregnant or breastfeeding
- Recent use of certain medications that might interfere with the study
Focus and goal of the trial:
The trial aims to determine if a new 10% permethrin cream is more effective than the standard 5% permethrin cream for treating scabies. The study follows a structured approach over up to 28 days. After joining the study and confirming your diagnosis, you will receive the first treatment with one of the two cream concentrations, assigned randomly. Neither you nor the researchers will know which concentration you receive, ensuring unbiased results. After 14 days, the effectiveness is evaluated. If needed, a second treatment is applied, followed by a final evaluation at 28 days.
Investigational drugs:
The trial uses two formulations of permethrin cream. Permethrin Cream 10% is the experimental treatment being tested for potentially superior effectiveness. Permethrin Cream 5% (InfectoScab® 5% Cream) serves as the comparison treatment, representing the current standard care. Both creams work by disrupting the nervous system of the mites, causing their paralysis and death. Permethrin belongs to a class of synthetic insecticides called pyrethroids.
Summary
Currently, only one clinical trial is actively recruiting patients with acarodermatitis. This trial is located in Germany and focuses specifically on comparing different concentrations of permethrin, a well-established treatment for this condition. The study addresses an important question about whether increasing the concentration of the active ingredient can improve treatment outcomes. The trial uses a rigorous double-blind design to ensure reliable results that could potentially improve the standard of care for people affected by this uncomfortable skin condition.
