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Clinical trials in Prague – page 13

1 231 clinical trials in Prague, Czechia across 17 research sites. Every trial is listed in the EU Clinical Trials Register and updated daily.

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Prague at a glance
1 231
clinical trials
  • Research sites17
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1 231 trials in Prague

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Phase 2b Randomized Double‑Blind Study of Oral PF‑08049820 in Adults with Moderate to Severe Atopic Dermatitis

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years
  • Sponsor:Pfizer Inc.

Obesity+1

Recruiting

A study to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight and type 2 diabetes

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:LY3841136 sodium
  • Sponsor:Eli Lilly & Co.

A study to evaluate the safety and effectiveness of filgotinib in children and adolescents aged 8 to 17 years with polyarticular juvenile idiopathic arthritis

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:0–17 years
  • Substances:Filgotinib
  • Sponsor:Alfasigma S.p.A.

Study of blinatumomab and a drug combination for older adults with newly diagnosed Philadelphia-negative B-cell precursor Acute Lymphoblastic Leukemia

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Asparaginase
  • Sponsor:Amgen Inc.

Study to evaluate the effect of omaveloxolone on mitochondrial function in patients with Friedreich's ataxia

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years · Healthy volunteers
  • Substances:Omaveloxolone
  • Sponsor:Fakultni Nemocnice V Motole

Comparing AZD5335 with mirvetuximab soravtansine or a drug combination in patients with platinum-resistant ovarian cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:AZD5335
  • Sponsor:AstraZeneca AB

A study of PF-08634404 and a drug combination in adults with advanced or metastatic non-small cell lung cancer

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:Pfizer Inc.

A study to evaluate the effectiveness and safety of REGN13335 in adults with pulmonary arterial hypertension

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:HUMAN IGG4 KAPPA MONOCLONAL ANTIBODY AGAINST PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
  • Sponsor:Regeneron Pharmaceuticals Inc.
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Zigakibart
  • Sponsor:Novartis Pharma AG

Glioma

Recruiting

A study of ulixertinib, tovorafenib, and vinblastine sulfate for children with progressive, relapsed, or refractory low-grade glioma

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:0–17 years · 18–64 years
  • Substances:Tovorafenib
  • Sponsor:Universitaetsklinikum Heidelberg AöR

A study to evaluate the safety and effectiveness of inhaled treprostinil in patients with pulmonary hypertension associated with interstitial lung disease

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Treprostinil
  • Sponsor:Liquidia Technologies Inc.

A study of pumitamig and a drug combination versus bevacizumab and a drug combination for patients with untreated, unresectable, or metastatic colorectal cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Bevacizumab
  • Sponsor:Bristol-Myers Squibb Services Unlimited Company

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Clinical research in Prague

What the registry says about research in the country

01 Neoplasms and Oncology

Clinical trial activity in Praha includes research in advanced melanoma and diffuse large B-cell lymphoma, with a strong focus on improving cancer control and extending survival.

  • Advanced melanoma
  • Previously untreated diffuse large B-cell lymphoma
  • Testing new treatment combinations
  • Evaluating survival outcomes and disease progression

These studies are designed to refine how immunotherapy and other cancer treatments perform in everyday clinical care.

02 Cardiovascular Diseases

Research in cardiovascular diseases is centered on reducing major heart and vascular events, with trials looking at hypertension, atherosclerotic cardiovascular disease, and heart failure prevention.

  • Hypertension
  • Atherosclerotic cardiovascular disease
  • Prevention of heart failure
  • Lowering the risk of stroke and other vascular complications

Several studies aim to improve treatment effectiveness for patients at elevated cardiovascular risk.

03 Respiratory Tract Diseases

Trials in the respiratory field focus on better symptom control and fewer flare-ups in chronic obstructive pulmonary disease, alongside ongoing work in infection-related lung illness.

  • Chronic obstructive pulmonary disease
  • Covid-19 in people at high risk of severe illness
  • Testing new antiviral and anti-inflammatory approaches
  • Reducing exacerbations and severe outcomes

These studies support more effective care for both chronic and acute respiratory conditions.

04 Skin and Connective Tissue Diseases

Dermatology research in Czechia includes several inflammatory skin disorders, with studies targeting itch, lesion control, and long-term disease management.

  • Atopic dermatitis
  • Moderate to severe plaque psoriasis
  • Hidradenitis suppurativa
  • Neurodermatitis and lichen simplex chronicus

The goal is to evaluate new therapies that may ease symptoms and improve quality of life.

05 Immune System Diseases

Studies in immune-mediated disease are exploring treatments that can calm abnormal inflammation while maintaining safety and tolerability.

  • Psoriatic arthritis
  • Atopic dermatitis
  • Psoriasis-related inflammatory conditions
  • Assessing immune-targeted therapy effectiveness

These trials aim to improve control of chronic immune-driven disease burden.

06 Nervous System Diseases

Neurology-related research focuses on agitation in Alzheimer's disease dementia, with efforts to better manage behavioral symptoms that affect patients and caregivers.

  • Agitation in Alzheimer's disease dementia
  • Symptom relief and behavioral improvement
  • Evaluating new therapeutic options

These studies may help support more practical care for people living with dementia.

07 Nutritional and Metabolic Diseases

Metabolic research in Praha includes trials for overweight, obesity, and related conditions, often linked with cardiovascular risk.

  • Overweight and obesity
  • Hypertension with obesity
  • Type 2 diabetes-related weight management
  • Supporting weight loss and cardiometabolic health

These studies are testing approaches that may help reduce long-term health risks tied to excess weight.

08 Virus Diseases

In the area of virus diseases, research is centered on improving treatment options for people with COVID-19 who are at higher risk of becoming seriously ill.

  • COVID-19 at high risk of progression
  • Reducing illness severity
  • Testing antiviral treatment effectiveness

The main aim is to help prevent worsening disease and support faster recovery.

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